| Literature DB >> 10087918 |
B E Kemp1, K I Mitchelhill, D Stapleton, B J Michell, Z P Chen, L A Witters.
Abstract
The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism through to transcriptional control.Entities:
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Year: 1999 PMID： 10087918 DOI： 10.1016/s0968-0004(98)01340-1
Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807