Literature DB >> 10087608

The in vivo delivery of heterologous proteins by microencapsulated recombinant cells.

P L Chang1, J M Van Raamsdonk, G Hortelano, S C Barsoum, N C MacDonald, T L Stockley.   

Abstract

The microencapsulation of recombinant cells is a novel and potentially cost-effective method of heterologous protein delivery. A 'universal' cell line, genetically modified to secrete any desired protein, is immunologically protected from tissue rejection by enclosure in microcapsules. The microcapsule can then be implanted in different recipients to deliver recombinant proteins in vivo.

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Year:  1999        PMID： 10087608     DOI： 10.1016/s0167-7799(98)01250-5

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  5 in total

Review 1.  Cell microencapsulation: a potential tool for the treatment of neuronopathic lysosomal storage diseases.

Authors:  Ursula Matte; Valeska Lizzi Lagranha; Talita Giacomet de Carvalho; Fabiana Quoos Mayer; Roberto Giugliani
Journal:  J Inherit Metab Dis       Date:  2011-05-26       Impact factor: 4.982

2.  Preparation and in vitro studies of microencapsulated cells releasing human tissue inhibitor of metalloproteinase-2.

Authors:  Qiang Jiang; Su-Zhan Zhang; Jia-Ping Peng; Xu-Lin Wang
Journal:  J Zhejiang Univ Sci B       Date:  2005-09       Impact factor: 3.066

Review 3.  Natural polymers for the microencapsulation of cells.

Authors:  Luca Gasperini; João F Mano; Rui L Reis
Journal:  J R Soc Interface       Date:  2014-11-06       Impact factor: 4.118

4.  Fabrication principles and their contribution to the superior in vivo therapeutic efficacy of nano-liposomes remote loaded with glucocorticoids.

Authors:  Yuval Avnir; Keren Turjeman; Deborah Tulchinsky; Alex Sigal; Pablo Kizelsztein; Dina Tzemach; Alberto Gabizon; Yechezkel Barenholz
Journal:  PLoS One       Date:  2011-10-06       Impact factor: 3.240

5.  Potentiated Osteoinductivity via Cotransfection with BMP-2 and VEGF Genes in Microencapsulated C2C12 Cells.

Authors:  Yang Shen; Han Qiao; Qiming Fan; Shuhong Zhang; Tingting Tang
Journal:  Biomed Res Int       Date:  2015-09-16       Impact factor: 3.411
  5 in total

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