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Literature DB >> 10087605

Future prospects for artificial blood.

Abstract

Concern about potential infective agents in donated blood has stimulated the recent development of blood substitutes. Chemically cross-linked hemoglobins are already undergoing clinical trials and might soon be ready for routine use. New generations of modified hemoglobin are being prepared to modulate the effects of nitric oxide and oxygen radicals, and artificial red blood cells are also under development.

Entities: Chemical

Mesh：

Substances：

Year: 1999 PMID： 10087605 DOI： 10.1016/s0167-7799(98)01242-6

Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536

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Cited

8 in total

Review 1. Drugs for increasing oxygen and their potential use in doping: a review.

Authors: Aurelie Gaudard; Emmanuelle Varlet-Marie; Francoise Bressolle; Michel Audran
Journal: Sports Med Date: 2003 Impact factor: 11.136

2. Influence of the chemistry of conjugation of poly(ethylene glycol) to Hb on the oxygen-binding and solution properties of the PEG-Hb conjugate.

Authors: Tao Hu; Muthuchidambaram Prabhakaran; Seetharama A Acharya; Belur N Manjula
Journal: Biochem J Date: 2005-12-15 Impact factor: 3.857

3. Extension arm facilitated PEGylation of hemoglobin: correlation of the properties with the extent of PEGylation.

Authors: Dongxia Li; Belur N Manjula; A Seetharama Acharya
Journal: Protein J Date: 2006-06 Impact factor: 2.371

4. Influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated haemoglobin.

Authors: Tao Hu; Belur N Manjula; Dongxia Li; Michael Brenowitz; Seetharama A Acharya
Journal: Biochem J Date: 2007-02-15 Impact factor: 3.857

5. Non-hypertensive tetraPEGylated canine haemoglobin: correlation between PEGylation, O2 affinity and tissue oxygenation.

Authors: Seetharama A Acharya; Vivek N Acharya; Nirmala Devi Kanika; Amy G Tsai; Marcos Intaglietta; Belur N Manjula
Journal: Biochem J Date: 2007-08-01 Impact factor: 3.857

Future prospects for artificial blood.

Review 1. Drugs for increasing oxygen and their potential use in doping: a review.

2. Influence of the chemistry of conjugation of poly(ethylene glycol) to Hb on the oxygen-binding and solution properties of the PEG-Hb conjugate.

3. Extension arm facilitated PEGylation of hemoglobin: correlation of the properties with the extent of PEGylation.

4. Influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated haemoglobin.

5. Non-hypertensive tetraPEGylated canine haemoglobin: correlation between PEGylation, O2 affinity and tissue oxygenation.

Review 6. Doping with artificial oxygen carriers: an update.

7. Artificial Cell Therapy: New Strategies for the Therapeutic Delivery of Live Bacteria.

8. Potentials and limitations of microorganisms as renal failure biotherapeutics.