| Literature DB >> 10087313 |
Y Tsuchida1, Y Hayashi, K Asami, K Yamamoto, J Yokoyama, H Mugishima, T Honna, J Mimaya, F Hara, T Sawada, T Matsumura, S Suita, T Sugimoto, M Kaneko.
Abstract
The efficacy of granisetron hydrochloride 20 microg/kg and 40 microg/kg were compared using a cross-over method to determine the optimal dose in children with solid tumors receiving high-dose chemotherapy. Granisetron controlled the onset of vomiting in 17 of 23 patients (73.9%) who were given 40 microg/kg of granisetron, while 8 of 21 patients (38.1%) were free of vomiting in the 20 microg/kg group. The average frequency of vomiting was 7.22 times in the 20 microg/kg dose versus 4.44 times in the 40 microg/kg dose. No safety problems were associated with either dose. The 40 microg/kg dose of granisetron appears to be more optimal.Entities:
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Year: 1999 PMID： 10087313 DOI： 10.3892/ijo.14.4.673
Source DB: PubMed Journal: Int J Oncol ISSN： 1019-6439 Impact factor: 5.650