CMAP amplitude cartography of muscles innervated by the median, ulnar, peroneal, and tibial nerves.

The spatial and temporal distribution of compound muscle action potential (CMAP) amplitudes was mapped using 1 x 1-cm grids over thenar, hypothenar, dorsal foot, and foot sole muscles (seven maps each). The high-amplitude zone (HAZ, area where amplitudes were over 80% of the maximum amplitude) denoted susceptibility to changes in recording site. Thenar maps had one peak (spatially and temporally) with a HAZ of 3.5 +/- 2.3 cm2. Hypothenar maps had two peaks (spatially and temporally) with a HAZ of 7.7 +/- 3.6 cm2. Dorsal foot maps had one temporal peak, which could be split up spatially; the HAZ was smallest, at 1.7 +/- 1.7 cm2. Foot sole muscles had one peak (spatially and temporally), with the largest HAZ at 18.4 +/- 6.1 cm2. Wave-form differences were ascribed to differences in muscle anatomy, architecture, and variability. These explain differences in amplitude reproducibility between nerves and the differing effect that increasing electrode size has on reproducibility.