Literature DB >> 10085048

Adaptive immune response to Shigella flexneri 2a cydC in immunocompetent mice and mice lacking immunoglobulin A.

S S Way1, A C Borczuk, M B Goldberg.   

Abstract

Shigella flexneri cydC, which is deficient in cytochrome bd, was rapidly cleared from the lungs of intranasally inoculated mice and was Sereny negative, yet it induced 93% protection against challenge with wild-type S. flexneri. Mice that lack immunoglobulin A (IgA) were fully protected, suggesting that IgA may not be required for adaptive immunity in this model system.

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Year:  1999        PMID: 10085048      PMCID: PMC96558          DOI: 10.1128/IAI.67.4.2001-2004.1999

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  18 in total

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Review 4.  Clinical significance of IgA deficiency.

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5.  Human milk immunoglobulin A antibodies to Shigella virulence determinants.

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Authors:  S S Way; S Sallustio; R S Magliozzo; M B Goldberg
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9.  Antibody and cytokine responses in a mouse pulmonary model of Shigella flexneri serotype 2a infection.

Authors:  L L van de Verg; C P Mallett; H H Collins; T Larsen; C Hammack; T L Hale
Journal:  Infect Immun       Date:  1995-05       Impact factor: 3.441

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6.  Thymic independence of adaptive immunity to the intracellular pathogen Shigella flexneri serotype 2a.

Authors:  S S Way; A C Borczuk; M B Goldberg
Journal:  Infect Immun       Date:  1999-08       Impact factor: 3.441

7.  Comparison of OG1RF and an isogenic fsrB deletion mutant by transcriptional analysis: the Fsr system of Enterococcus faecalis is more than the activator of gelatinase and serine protease.

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8.  Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses.

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9.  Functional and Antigen-Specific Serum Antibody Levels as Correlates of Protection against Shigellosis in a Controlled Human Challenge Study.

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10.  Delayed accumulation of intestinal coliform bacteria enhances life span and stress resistance in Caenorhabditis elegans fed respiratory deficient E. coli.

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  10 in total

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