W S Aronow1, C Ahn. 1. Hebrew Hospital Home, Bronx, NY 10475, USA.
Abstract
STUDY OBJECTIVES: To investigate in older persons whether diabetes mellitus is an independent risk factor for congestive heart failure (CHF). DESIGN: A prospective study was performed in 2,737 older persons investigating the incidence of new CHF in persons with and without diabetes mellitus. SETTING: A long-term health-care facility. PATIENTS: Eight hundred sixty-five men and 1,872 women, with a mean age of 81+/-9 years. MEASUREMENTS AND RESULTS: At 43-month follow-up, new CHF developed in 272 of 690 persons (39%) with diabetes mellitus and in 467 of 2,047 persons (23%) without diabetes mellitus (p < 0.0001). Cox regression analysis showed that age (p = 0.0001, risk ratio = 1.048), hypertension (p = 0.0001, risk ratio = 2.524), coronary artery disease (p = 0.0001, risk ratio = 4.008), male gender (p = 0.0001, risk ratio = 1.399), and diabetes mellitus (p = 0.0003, risk ratio = 1.337) were significantly positively associated with the time to the development of CHF. CONCLUSIONS: Older persons with diabetes mellitus had a 1.3 times higher chance of developing CHF than those without diabetes mellitus after controlling the confounding effects of other prognostic variables.
STUDY OBJECTIVES: To investigate in older persons whether diabetes mellitus is an independent risk factor for congestive heart failure (CHF). DESIGN: A prospective study was performed in 2,737 older persons investigating the incidence of new CHF in persons with and without diabetes mellitus. SETTING: A long-term health-care facility. PATIENTS: Eight hundred sixty-five men and 1,872 women, with a mean age of 81+/-9 years. MEASUREMENTS AND RESULTS: At 43-month follow-up, new CHF developed in 272 of 690 persons (39%) with diabetes mellitus and in 467 of 2,047 persons (23%) without diabetes mellitus (p < 0.0001). Cox regression analysis showed that age (p = 0.0001, risk ratio = 1.048), hypertension (p = 0.0001, risk ratio = 2.524), coronary artery disease (p = 0.0001, risk ratio = 4.008), male gender (p = 0.0001, risk ratio = 1.399), and diabetes mellitus (p = 0.0003, risk ratio = 1.337) were significantly positively associated with the time to the development of CHF. CONCLUSIONS: Older persons with diabetes mellitus had a 1.3 times higher chance of developing CHF than those without diabetes mellitus after controlling the confounding effects of other prognostic variables.
Authors: Javed Butler; Andreas P Kalogeropoulos; Vasiliki V Georgiopoulou; Kirsten Bibbins-Domingo; Samer S Najjar; Kim C Sutton-Tyrrell; Tamara B Harris; Stephen B Kritchevsky; Donald M Lloyd-Jones; Anne B Newman; Bruce M Psaty Journal: Heart Date: 2011-06-02 Impact factor: 5.994
Authors: Brita Roy; Pushkar P Pawar; Ravi V Desai; Gregg C Fonarow; Marjan Mujib; Yan Zhang; Margaret A Feller; Fernando Ovalle; Inmaculada B Aban; Thomas E Love; Ami E Iskandrian; Prakash Deedwania; Ali Ahmed Journal: Am J Cardiol Date: 2011-09-22 Impact factor: 2.778
Authors: Raghava S Velagaleti; Philimon Gona; Michael L Chuang; Carol J Salton; Caroline S Fox; Susan J Blease; Susan B Yeon; Warren J Manning; Christopher J O'Donnell Journal: Circ Cardiovasc Imaging Date: 2010-03-05 Impact factor: 7.792
Authors: Giovanni de Simone; Richard B Devereux; Marcello Chinali; Elisa T Lee; James M Galloway; Ana Barac; Julio A Panza; Barbara V Howard Journal: J Hypertens Date: 2010-02 Impact factor: 4.844
Authors: Omar Asghar; Ahmed Al-Sunni; Kaivan Khavandi; Ali Khavandi; Sarah Withers; Adam Greenstein; Anthony M Heagerty; Rayaz A Malik Journal: Clin Sci (Lond) Date: 2009-05 Impact factor: 6.124