Literature DB >> 10083740

Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the human nuclear factor kappa-beta subunit 1 (NFKB1) locus.

N Ota1, T Nakajima, Y Shirai, M Emi.   

Abstract

The transcriptional factor nuclear factor kappa-beta (NFKB) consists of a multicomponent protein complex that plays a major role in the regulation of many viral and cellular genes. The NFKB complex has two alternative DNA binding subunits. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the NFKB subunit 1 (NFKB1) gene located at 4q23-24. High heterozygosity (0.813) makes this polymorphism a useful marker in the genetic study of disorders affecting the immune response and cell differentiation.

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Year:  1999        PMID： 10083740     DOI： 10.1007/s100380050125

Source DB:  PubMed          Journal:  J Hum Genet        ISSN： 1434-5161            Impact factor:   3.172


  5 in total

1.  Genetic polymorphisms of NFκB1 -94 del/ins ATTG, NFκB1A 2758 A>G and SUMO rs237025 G>A in psoriasis.

Authors:  Abdullateef A Alzolibani; Ahmed Settin; Ahmed Ali Ahmed; Hisham Ismail; Noor Elhefni; Ahmad A Al Robaee
Journal:  Int J Health Sci (Qassim)       Date:  2015-01

2.  NFκB1 and NFκBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population.

Authors:  Shunxin Song; Dianke Chen; Jiachun Lu; Jiawei Liao; Yanxin Luo; Zuli Yang; Xinhui Fu; Xinjuan Fan; Yisheng Wei; Lei Yang; Lei Wang; Jianping Wang
Journal:  PLoS One       Date:  2011-06-30       Impact factor: 3.240

3.  RNA sequencing identifies gene expression profile changes associated with β-estradiol treatment in U2OS osteosarcoma cells.

Authors:  Bin Chen; Zude Liu; Jidong Zhang; Hantao Wang; Bo Yu
Journal:  Onco Targets Ther       Date:  2017-07-11       Impact factor: 4.147

Review 4.  Genetic Association Between NFKBIA -881A>G Polymorphism and Cancer Susceptibility.

Authors:  Peiliang Geng; Juanjuan Ou; Jianjun Li; Yunmei Liao; Ning Wang; Rina Sa; Lisha Xiang; Houjie Liang
Journal:  Medicine (Baltimore)       Date:  2015-08       Impact factor: 1.889

Review 5.  Significant association between rs28362491 polymorphism in NF-κB1 gene and coronary artery disease: a meta-analysis.

Authors:  Yanwei Wang; Bianwen Wu; Muqing Zhang; Huawei Miao; Jiaan Sun
Journal:  BMC Cardiovasc Disord       Date:  2020-06-08       Impact factor: 2.298
  5 in total

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