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Literature DB >> 10082875

Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons.

K Shinpo¹, S Kikuchi, F Moriwaka, K Tashiro.

Abstract

Pretreatments with TNF-alpha and lower concentrations of C2-ceramide protected cultured mesencephalic neurons from excitotoxicity in a dose-dependent manner. These protective effects are reduced by cotreatment with N,N-dimethylsphingosine (DMS), an inhibitor of sphingosine kinase. Since the pretreatment with sphingosine-1-phosphate (SPP) showed a neuroprotective effect, our data suggest that protective effects of TNF and C2-ceramide could be attributable to their further metabolism to SPP. Copyright 1999 Elsevier Science B.V.

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Year: 1999 PMID： 10082875 DOI： 10.1016/s0006-8993(98)01354-7

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

16 in total

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Authors: R Diem; R Meyer; J H Weishaupt; M Bahr
Journal: J Neurosci Date: 2001-03-15 Impact factor: 6.167

2. beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

Authors: C K Combs; J C Karlo; S C Kao; G E Landreth
Journal: J Neurosci Date: 2001-02-15 Impact factor: 6.167

Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons.

1. Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell death in vivo.

2. beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

3. Ethanol triggers sphingosine 1-phosphate elevation along with neuroapoptosis in the developing mouse brain.

4. Protection by D609 through cell-cycle regulation after stroke.

5. Lack of TNF-alpha promotes caspase-3-independent apoptosis during murine cytomegalovirus retinitis.

6. Effects of small interfering RNA targeting sphingosine kinase-1 gene on the animal model of Alzheimer's disease.

7. Dual effects of TNFalpha on nerve fiber formation from ventral mesencephalic organotypic tissue cultures.

Review 8. Regulation and functions of sphingosine kinases in the brain.

Review 9. Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis.

10. Distribution of sphingosine kinase activity and mRNA in rodent brain.