Literature DB >> 10082848

BDNF and NT-4, but not NT-3, promote development of inhibitory synapses in the absence of neuronal activity.

F J Seil1.   

Abstract

Development of the full complement of inhibitory synapses in cerebellar cultures requires the presence of neuronal activity. The neurotrophins, BDNF, NT-3 and NT-4, were applied to cerebellar explants during activity blockade. Control numbers of inhibitory Purkinje cell axosomatic synapses developed in the presence of the TrkB receptor ligands, BDNF and NT-4, but not the TrkC receptor ligand, NT-3. The results suggest that BDNF and NT-4 have a role in the promotion of activity-dependent inhibitory synaptogenesis. Copyright 1999 Elsevier Science B.V.

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Year:  1999        PMID： 10082848     DOI： 10.1016/s0006-8993(98)01304-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

Review 1.  Activity-dependent modulation of inhibition in Purkinje cells by TrkB ligands.

Authors:  Rosemarie Drake-Baumann
Journal:  Cerebellum       Date:  2006       Impact factor: 3.847

2.  Neuronal activity and brain-derived neurotrophic factor regulate the density of inhibitory synapses in organotypic slice cultures of postnatal hippocampus.

Authors:  S Marty; R Wehrlé; C Sotelo
Journal:  J Neurosci       Date:  2000-11-01       Impact factor: 6.167

3.  TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis.

Authors:  F J Seil; R Drake-Baumann
Journal:  J Neurosci       Date:  2000-07-15       Impact factor: 6.167

4.  Promoter specific alterations of brain-derived neurotrophic factor mRNA in schizophrenia.

Authors:  J Wong; T M Hyde; H L Cassano; A Deep-Soboslay; J E Kleinman; C Shannon Weickert
Journal:  Neuroscience       Date:  2010-05-27       Impact factor: 3.590

5.  Differential cellular expression of neurotrophins in cortical tubers of the tuberous sclerosis complex.

Authors:  R Kyin; Y Hua; M Baybis; B Scheithauer; D Kolson; E Uhlmann; D Gutmann; P B Crino
Journal:  Am J Pathol       Date:  2001-10       Impact factor: 4.307

Review 6.  The changeable nervous system: studies on neuroplasticity in cerebellar cultures.

Authors:  Fredrick J Seil
Journal:  Neurosci Biobehav Rev       Date:  2014-06-13       Impact factor: 8.989

7.  A new aspect of the TrkB signaling pathway in neural plasticity.

Authors:  K Ohira; M Hayashi
Journal:  Curr Neuropharmacol       Date:  2009-12       Impact factor: 7.363

8.  Inflammatory demyelination alters subcortical visual circuits.

Authors:  Sheila Espírito Santo Araújo; Henrique Rocha Mendonça; Natalie A Wheeler; Paula Campello-Costa; Kimberle M Jacobs; Flávia C A Gomes; Michael A Fox; Babette Fuss
Journal:  J Neuroinflammation       Date:  2017-08-18       Impact factor: 8.322

Review 9.  Activity-Dependent Inhibitory Synaptogenesis in Cerebellar Cultures.

Authors:  Fredrick John Seil
Journal:  Brain Plast       Date:  2016-06-29

10.  Robot-Embodied Neuronal Networks as an Interactive Model of Learning.

Authors:  Abraham M Shultz; Sangmook Lee; Mary Guaraldi; Thomas B Shea; Holly C Yanco
Journal:  Open Neurol J       Date:  2017-09-30
  10 in total

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