Literature DB >> 10081603

Modulation of formalin-evoked hyperalgesia by intrathecal N-type Ca channel and protein kinase C inhibitor in the rat.

O Nakanishi1, T Ishikawa, Y Imamura.   

Abstract

1. omega-CgTx attenuated formalin-evoked biphasic flinches, while PKC inhibitor (STU) attenuated phase 2 and was reversed by PDBu. 2. omega-CgTx and STU suppressed the increase in CSF-glutamate after formalin injection. 3. Morphine completely suppressed both increased flinching and CSF glutamate release. 4. Thus, omega-CgTx (N-type Ca channels) may regulate neurotransmitter release evoked by C fiber activation and the formalin-evoked hyperalgesia may possibly be provoked as a result of PKC activation elicited by both presynaptic neurotransmitter release and activation of NMDA receptors in the spinal neurons.

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Year:  1999        PMID： 10081603     DOI： 10.1023/a:1006937209676

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  19 in total

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Journal:  Neurosci Lett       Date:  1990-07-03       Impact factor: 3.046

5.  Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model.

Authors:  Christopher W Murray; Alan Cowan; Alice A Larson
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Authors:  A B Malmberg; T L Yaksh
Journal:  Anesthesiology       Date:  1993-08       Impact factor: 7.892

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Authors:  T L Yaksh; T A Rudy
Journal:  Physiol Behav       Date:  1976-12

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Authors:  M Ocaña; J M Baeyens
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9.  Morphine activates omega-conotoxin-sensitive Ca2+ channels to release adenosine from spinal cord synaptosomes.

Authors:  C M Cahill; T D White; J Sawynok
Journal:  J Neurochem       Date:  1993-03       Impact factor: 5.372

10.  Phorbol ester suppression of opioid analgesia in rats.

Authors:  L J Zhang; X J Wang; J S Han
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  6 in total

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6.  Activation of protein kinase C in the spinal cord produces mechanical hyperalgesia by activating glutamate receptors, but does not mediate chronic muscle-induced hyperalgesia.

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  6 in total

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