Literature DB >> 10080919

Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin.

N Ide1, Y Hata, M Deguchi, K Hirao, I Yao, Y Takai.   

Abstract

Synaptic scaffolding molecule (S-SCAM) is a multiple PDZ domain-containing protein, which interacts with neuroligin, a cell adhesion molecule, and the NMDA receptor. In this study, we searched for S-SCAM-interacting proteins and obtained a neuralplakophilin-related armadillo-repeat protein (NPRAP)/delta-catenin. NPRAP/delta-catenin bound to the last PDZ domain of S-SCAM via its carboxyl-terminus in three different cell-free assay systems, was coimmunoprecipitated with S-SCAM from rat crude synaptosomes, and was localized at the excitatory synapses in rat hippocampal neurons. NPRAP/delta-catenin may be implicated in the molecular organization of synaptic junctions through the interaction with S-SCAM. Copyright 1999 Academic Press.

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Year:  1999        PMID： 10080919     DOI： 10.1006/bbrc.1999.0364

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  26 in total

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