Literature DB >> 10080656

Quantitative determination of trimethylamine in urine by solid-phase microextraction and gas chromatography-mass spectrometry.

G A Mills1, V Walker, H Mughal.   

Abstract

Trimethylaminuria (fish odour syndrome) is diagnosed from an increase in urinary excretion of trimethylamine with decreased trimethylamine oxide. We report a new quantitative stable isotope dilution gas chromatography-mass spectrometry procedure for the analysis of these metabolites using solid-phase microextraction (SPME). Both polydimethylsiloxane and mixed Carboxen-polydimethylsiloxane SPME fibres were found to be suitable for the headspace extraction of TMA. This new sampling technique could have wide application for the analysis of volatile and semi-volatile compounds by metabolic screening laboratories.

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Year:  1999        PMID： 10080656     DOI： 10.1016/s0378-4347(98)00542-8

Source DB:  PubMed          Journal:  J Chromatogr B Biomed Sci Appl        ISSN： 1387-2273


  10 in total

1.  Trimethylaminuria: causes and diagnosis of a socially distressing condition.

Authors:  Richard J Mackay; Christopher J McEntyre; Caroline Henderson; Michael Lever; Peter M George
Journal:  Clin Biochem Rev       Date:  2011-02

2.  Major odorants released as urinary volatiles by urinary incontinent patients.

Authors:  Sudhir Kumar Pandey; Ki-Hyun Kim; Si On Choi; In Young Sa; Soo Yeon Oh
Journal:  Sensors (Basel)       Date:  2013-07-03       Impact factor: 3.576

3.  Blood Trimethylamine-N-Oxide Originates from Microbiota Mediated Breakdown of Phosphatidylcholine and Absorption from Small Intestine.

Authors:  Wolfgang Stremmel; Kathrin V Schmidt; Vera Schuhmann; Frank Kratzer; Sven F Garbade; Claus-Dieter Langhans; Gert Fricker; Jürgen G Okun
Journal:  PLoS One       Date:  2017-01-27       Impact factor: 3.240

4.  A highly sensitive liquid chromatography electrospray ionization mass spectrometry method for quantification of TMA, TMAO and creatinine in mouse urine.

Authors:  Sunil Veeravalli; Kersti Karu; Ian R Phillips; Elizabeth A Shephard
Journal:  MethodsX       Date:  2017-09-28

5.  Simultaneous Measurement of Urinary Trimethylamine (TMA) and Trimethylamine N-Oxide (TMAO) by Liquid Chromatography-Mass Spectrometry.

Authors:  Xun Jia; Lucas J Osborn; Zeneng Wang
Journal:  Molecules       Date:  2020-04-17       Impact factor: 4.411

6.  Derivatization-free determination of short-chain volatile amines in human plasma and urine by headspace gas chromatography-mass spectrometry.

Authors:  Peter Neyer; Luca Bernasconi; Jens A Fuchs; Martina D Allenspach; Christian Steuer
Journal:  J Clin Lab Anal       Date:  2019-10-08       Impact factor: 2.352

7.  Gut microbiota derived trimethylamine N-oxide (TMAO) detection through molecularly imprinted polymer based sensor.

Authors:  G B V S Lakshmi; Amit K Yadav; Neha Mehlawat; Rekha Jalandra; Pratima R Solanki; Anil Kumar
Journal:  Sci Rep       Date:  2021-01-14       Impact factor: 4.379

8.  Electrophoretic Determination of Trimethylamine (TMA) in Biological Samples as a Novel Potential Biomarker of Cardiovascular Diseases Methodological Approach.

Authors:  Marek Konop; Mateusz Rybka; Emilia Waraksa; Anna K Laskowska; Artur Nowiński; Tomasz Grzywacz; Wojciech J Karwowski; Adrian Drapała; Ewa Maria Kłodzińska
Journal:  Int J Environ Res Public Health       Date:  2021-11-23       Impact factor: 3.390

9.  Electrochemical Trimethylamine N-Oxide Biosensor with Enzyme-Based Oxygen-Scavenging Membrane for Long-Term Operation under Ambient Air.

Authors:  Armel F T Waffo; Biljana Mitrova; Kim Tiedemann; Chantal Iobbi-Nivol; Silke Leimkühler; Ulla Wollenberger
Journal:  Biosensors (Basel)       Date:  2021-03-27

10.  Searching for Potential Markers of Glomerulopathy in Urine by HS-SPME-GC×GC TOFMS.

Authors:  Tomasz Ligor; Joanna Zawadzka; Grzegorz Strączyński; Rosa M González Paredes; Anna Wenda-Piesik; Ileana Andreea Ratiu; Marek Muszytowski
Journal:  Molecules       Date:  2021-03-24       Impact factor: 4.411
  10 in total

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