Literature DB >> 10078862

Application of immunoaffinity chromatography for detection of tetrodotoxin from urine samples of poisoned patients.

K Kawatsu1, T Shibata, Y Hamano.   

Abstract

Immunoaffinity chromatography using the monoclonal antibody (Tl-1) specific for tetrodotoxin (TTX) has been developed for isolating TTX from urine samples. By combining immunoaffinity chromatography with fluorometric high performance liquid chromatography (HPLC), it has become possible to detect a small amount of TTX in urine samples. The detection limit of TTX in urine was 2 ng/ml. By this combined method, TTX was detected in all the urine samples that were collected from poisoned patients during the week following TTX ingestion. The combination of immunoaffinity chromatography with HPLC was very useful in detecting TTX from the urine samples of poisoned patients for diagnosis of TTX-food poisoning.

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Year:  1999        PMID： 10078862     DOI： 10.1016/s0041-0101(98)00116-0

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  7 in total

Review 1.  Analytical challenges: determination of tetrodotoxin in human urine and plasma by LC-MS/MS.

Authors:  Kelvin Sze-Yin Leung; Bonnie Mei-Wah Fong; Yeuk-Ki Tsoi
Journal:  Mar Drugs       Date:  2011-11-08       Impact factor: 6.085

2.  Aptameric Recognition-Modulated Electroactivity of Poly(4-Styrenesolfonic Acid)-Doped Polyaniline Films for Single-Shot Detection of Tetrodotoxin.

Authors:  Gertrude Fomo; Tesfaye T Waryo; Christopher E Sunday; Abd A Baleg; Priscilla G Baker; Emmanuel I Iwuoha
Journal:  Sensors (Basel)       Date:  2015-09-08       Impact factor: 3.576

Review 3.  Tetrodotoxin: chemistry, toxicity, source, distribution and detection.

Authors:  Vaishali Bane; Mary Lehane; Madhurima Dikshit; Alan O'Riordan; Ambrose Furey
Journal:  Toxins (Basel)       Date:  2014-02-21       Impact factor: 4.546

Review 4.  Potential Threats Posed by Tetrodotoxins in UK Waters: Examination of Detection Methodology Used in Their Control.

Authors:  Andrew D Turner; Cowan Higgins; Wendy Higman; James Hungerford
Journal:  Mar Drugs       Date:  2015-12-11       Impact factor: 5.118

5.  Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin.

Authors:  Paula Abal; M Carmen Louzao; Natalia Vilariño; Mercedes R Vieytes; Luis M Botana
Journal:  Toxins (Basel)       Date:  2019-05-29       Impact factor: 4.546

Review 6.  The Incidence of Marine Toxins and the Associated Seafood Poisoning Episodes in the African Countries of the Indian Ocean and the Red Sea.

Authors:  Isidro José Tamele; Marisa Silva; Vitor Vasconcelos
Journal:  Toxins (Basel)       Date:  2019-01-21       Impact factor: 4.546

Review 7.  Development of standardized methodology for identifying toxins in clinical samples and fish species associated with tetrodotoxin-borne poisoning incidents.

Authors:  Tai-Yuan Chen; Cheng-Hong Hsieh; Deng-Fwu Hwang
Journal:  J Food Drug Anal       Date:  2015-07-21       Impact factor: 6.157
  7 in total

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