Literature DB >> 10077836

Molecular characterization of a carbapenem-hydrolyzing beta-lactamase from Chryseobacterium (Flavobacterium) indologenes.

S Bellais1, S Léotard, L Poirel, T Naas, P Nordmann.   

Abstract

Chryseobacterium (Flavobacterium) indologenes 001 clinical strain was resistant to several beta-lactam classes including carbapenems. Shotgun cloning experiments of Sau3AI restricted genomic DNA of C. indologenes 001 into pBKCMV cloning vector followed by transformation into Escherichia coli DH10B gave one recombinant plasmid possessing a 4.2-kb DNA insert. It encoded a pI 7.2 beta-lactamase of 239 amino acids (IND-1) which is a metallo-enzyme with a broad spectrum beta-lactam hydrolysis profile. This class B carbapenem-hydrolyzing beta-lactamase shares the highest identity (43%) with BlaB from C. meningosepticum, thus showing heterogeneity of carbapenem-hydrolyzing beta-lactamases in Chryseobacterium spp.

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Year:  1999        PMID： 10077836     DOI： 10.1111/j.1574-6968.1999.tb13422.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  31 in total

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Review 4.  Beta-lactamase nomenclature.

Authors:  George A Jacoby
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5.  Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny.

Authors:  M L Riccio; N Franceschini; L Boschi; B Caravelli; G Cornaglia; R Fontana; G Amicosante; G M Rossolini
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

6.  Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum.

Authors:  S Bellais; D Aubert; T Naas; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2000-07       Impact factor: 5.191

7.  Whole-Genome Analysis of an Extensively Drug-Resistance Empedobacter falsenii Strain Reveals Distinct Features and the Presence of a Novel Metallo-ß-Lactamase (EBR-2).

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Journal:  Curr Microbiol       Date:  2018-04-23       Impact factor: 2.188

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Journal:  Antimicrob Agents Chemother       Date:  2002-10       Impact factor: 5.191

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10.  Evaluation of a new Etest for detecting metallo-beta-lactamases in routine clinical testing.

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