Literature DB >> 10077679

Phenomenological theory of mortality evolution: its singularities, universality, and superuniversality.

M Y Azbel'1.   

Abstract

The probability to survive to the age x universally increases with the mean lifespan x(bar). For species as remote as humans and flies, for a given x the rate of its evolution with x is constant, except for the narrow vicinity of a certain x(bar) = x* (which equals 75 years for humans and 32 days for flies and which is independent of age, population, and living conditions). At x(bar) approximately x* the evolution rate jumps to a different value. Its next jump is predicted at x(bar) approximately 87 years for humans and approximately 59 days for flies. Such singularities are well known in physics and mathematics as phase transitions. In the considered case different population "phases" have significantly different survival evolution rates. The evolution is rapid-life expectancy may double within a lifespan of a single generation. Survival probability depends on age x and mean longevity x(bar) only (for instance, survival curves of 1896 Swedes and 1947 Japanese with approximately equal x(bar) are very close, although they are related to different races in different countries at different periods in their different history.) With no adjustable parameters, its presented universal law quantitatively agrees with all lifetable data. According to this law, the impact of all factors but age reduces to the mean lifespan only. In advanced and old age, this law is superuniversal--it is approximately the same for species as remote as humans and flies. It yields survival probability that linearly depends on the mean lifespan x(bar). As a result, when human x(bar) almost doubles (from 35.5 to 69.3 years), life expectancy at 70 years increases from 8 to 9.5 years only. Other implications of the universal law are also considered.

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Year:  1999        PMID: 10077679      PMCID: PMC15937          DOI: 10.1073/pnas.96.6.3303

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  22 in total

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4.  Genes that regulate both development and longevity in Caenorhabditis elegans.

Authors:  P L Larsen; P S Albert; D L Riddle
Journal:  Genetics       Date:  1995-04       Impact factor: 4.562

5.  A C. elegans mutant that lives twice as long as wild type.

Authors:  C Kenyon; J Chang; E Gensch; A Rudner; R Tabtiang
Journal:  Nature       Date:  1993-12-02       Impact factor: 49.962

6.  Explaining fruit fly longevity.

Authors:  A Kowald; T B Kirkwood
Journal:  Science       Date:  1993-06-11       Impact factor: 47.728

7.  Compositional interpretations of medfly mortality.

Authors:  J W Vaupel; J R Carey
Journal:  Science       Date:  1993-06-11       Impact factor: 47.728

8.  Punctuated equilibrium comes of age.

Authors:  S J Gould; N Eldredge
Journal:  Nature       Date:  1993-11-18       Impact factor: 49.962

9.  Mortality rates in a genetically heterogeneous population of Caenorhabditis elegans.

Authors:  A Brooks; G J Lithgow; T E Johnson
Journal:  Science       Date:  1994-02-04       Impact factor: 47.728

10.  Aging, genomic entropy and carcinogenesis: implications derived from longitudinal age-specific colon cancer mortality rate dynamics.

Authors:  J E Riggs
Journal:  Mech Ageing Dev       Date:  1993-12-31       Impact factor: 5.432

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  3 in total

1.  The role of intragenomic recombination rate in the evolution of population's genetic pool.

Authors:  Marta Zawierta; Przemysław Biecek; Wojciech Waga; Stanisław Cebrat
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3.  Empirical laws of survival and evolution: their universality and implications.

Authors:  M Y Azbel'
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

  3 in total

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