Literature DB >> 10077222

Chromosomal aberrations detected by comparative genomic hybridization (CGH) in human astrocytic tumors.

M Maruno1, T Yoshimine, A K Muhammad, H Ninomiya, A Kato, T Hayakawa.   

Abstract

We investigated chromosomal aberrations in 16 patients with astrocytic tumors of various histologic malignancies by comparative genomic hybridization (CGH). The degree of chromosomal loss was shown to be negatively correlated with histologic malignancy. Losses of portions of chromosomes 1p, 19q and 22q were the three chromosomal aberrations observed most frequently. Alterations in multiple chromosomes were observed more frequently in glioblastomas than in astrocytomas or anaplastic astrocytomas (P < 0.001). Primary glioblastomas showed a high frequency of genomic DNA gains (5/7), whereas recurrent glioblastomas from anaplastic astrocytomas did not (0/3). We found CGH to be a powerful tool for surveying DNA alterations in tumors and characterizing the biology of tumors of astrocytic lineage.

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Year:  1999        PMID： 10077222     DOI： 10.1016/s0304-3835(98)00266-3

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  6 in total

1.  Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases.

Authors:  C H Rickert; R Sträter; P Kaatsch; H Wassmann; H Jürgens; B Dockhorn-Dworniczak; W Paulus
Journal:  Am J Pathol       Date:  2001-04       Impact factor: 4.307

2.  Genomic alterations in low-grade, anaplastic astrocytomas and glioblastomas.

Authors:  Ali Arslantas; Sevilhan Artan; Ulkü Oner; M Hamza Müslümanoglu; Muhsin Ozdemir; Ramazan Durmaz; Didem Arslantas; Murat Vural; Erhan Cosan; Metin Ant Atasoy
Journal:  Pathol Oncol Res       Date:  2007-03-27       Impact factor: 3.201

3.  Detrended fluctuation analysis of genome-wide copy number profiles of glioblastomas using array-based comparative genomic hybridization.

Authors:  Yukiko Nakahara; Tetsuya Shiraishi; Hiroaki Okamoto; Toshihiro Mineta; Tsuyoshi Oishi; Kohsuke Sasaki; Kazuo Tabuchi
Journal:  Neuro Oncol       Date:  2004-10       Impact factor: 12.300

4.  The importance of genomic copy number changes in the prognosis of glioblastoma multiforme.

Authors:  Ali Arslantas; Sevilhan Artan; Ulkü Oner; Hamza Müslümanoğlu; Ramazan Durmaz; Erhan Cosan; Metin Ant Atasoy; Nurettin Başaran; Eşref Tel
Journal:  Neurosurg Rev       Date:  2003-07-04       Impact factor: 3.042

Review 5.  The evolution and application of techniques in molecular biology to human brain tumors: a 25 year perspective.

Authors:  James T Rutka; Paul Kongkham; Paul Northcott; Carlos Carlotti; Mustafa Guduk; Hirokatsu Osawa; Orlando Moreno; Ho Jun Seol; Andres Restrepo; Adrienne Weeks; Shoichi Nagai; Christian Smith
Journal:  J Neurooncol       Date:  2009-04-09       Impact factor: 4.130

6.  Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort.

Authors:  Saeko Hayashi; Hikaru Sasaki; Tokuhiro Kimura; Takayuki Abe; Takumi Nakamura; Yohei Kitamura; Tomoru Miwa; Kaori Kameyama; Yuichi Hirose; Kazunari Yoshida
Journal:  Oncotarget       Date:  2015-06-30
  6 in total

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