Literature DB >> 10076912

Immunity to tuberculosis: a delicate balance between protection and pathology.

S Ehlers1.   

Abstract

The currently used tuberculosis (TB) vaccine (Bacillus Calmette-Guérin) does not consistently prevent pulmonary infection. Novel vaccine strategies require an in-depth characterization of the cellular and molecular mechanisms of antituberculous protection. This review summarizes relevant data obtained in animal models of TB infection. In mycobacterial infections, immunologically mediated protection is intrinsically associated with tissue damage in the form of granuloma formation. The implications of this finding for future vaccine design and evaluation are discussed.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10076912     DOI： 10.1111/j.1574-695X.1999.tb01234.x

Source DB:  PubMed          Journal:  FEMS Immunol Med Microbiol        ISSN： 0928-8244


  17 in total

1.  Cytokine expression profiles of bovine lymph nodes: effects of Mycobacterium bovis infection and bacille Calmette-Guérin vaccination.

Authors:  S Widdison; L J Schreuder; B Villarreal-Ramos; C J Howard; M Watson; T J Coffey
Journal:  Clin Exp Immunol       Date:  2006-05       Impact factor: 4.330

2.  Identification of cytokines in whole blood for differential diagnosis of tuberculosis versus pneumonia.

Authors:  Wen-Lin Su; Wann-Cherng Perng; Ching-Hui Huang; Cheng-Yu Yang; Chin-Pyng Wu; Feng-Yee Chang; Jenn-Han Chen
Journal:  Clin Vaccine Immunol       Date:  2010-03-17

3.  Production of matrix metalloproteinases in response to mycobacterial infection.

Authors:  M Quiding-Järbrink; D A Smith; G J Bancroft
Journal:  Infect Immun       Date:  2001-09       Impact factor: 3.441

Review 4.  [Pathomorphogenesis of tubercular histologic changes: mechanisms of granuloma formation, maintenance and necrosis].

Authors:  S Ehlers
Journal:  Internist (Berl)       Date:  2003-11       Impact factor: 0.743

5.  Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection.

Authors:  Fredric Carlsson; Janice Kim; Calin Dumitru; Kai H Barck; Richard A D Carano; Mei Sun; Lauri Diehl; Eric J Brown
Journal:  PLoS Pathog       Date:  2010-05-06       Impact factor: 6.823

6.  Host genetics in granuloma formation: human-like lung pathology in mice with reciprocal genetic susceptibility to M. tuberculosis and M. avium.

Authors:  Elena Kondratieva; Nadya Logunova; Konstantin Majorov; Mikhail Averbakh; Alexander Apt
Journal:  PLoS One       Date:  2010-05-06       Impact factor: 3.240

7.  Characterization of human cellular immune responses to novel Mycobacterium tuberculosis antigens encoded by genomic regions absent in Mycobacterium bovis BCG.

Authors:  R Al-Attiyah; A S Mustafa
Journal:  Infect Immun       Date:  2008-06-23       Impact factor: 3.441

8.  The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection.

Authors:  Jun Sato; Jeffrey Schorey; Victoria A Ploplis; Erijka Haalboom; Liana Krahule; Francis J Castellino
Journal:  Am J Pathol       Date:  2003-08       Impact factor: 4.307

9.  A multicistronic DNA vaccine induces significant protection against tuberculosis in mice and offers flexibility in the expressed antigen repertoire.

Authors:  Fayaz-Ahmad Mir; Stefan H E Kaufmann; Ali Nasser Eddine
Journal:  Clin Vaccine Immunol       Date:  2009-08-05

10.  CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis.

Authors:  Darío A Fernández Do Porto; Javier O Jurado; Virginia Pasquinelli; Ivana B Alvarez; Romina H Aspera; Rosa M Musella; Verónica E García
Journal:  Immunol Cell Biol       Date:  2011-07-12       Impact factor: 5.126
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.