Literature DB >> 10076516

Expression of latent and replicative-infection genes of Epstein-Barr virus in macrophage.

M Shimakage1, M Kimura, S Yanoma, M Ibe, S Yokota, G Tsujino, T Kozuka, T Dezawa, S Tamura, A Ohshima, M Yutsudo, A Hakura.   

Abstract

Unlike other herpesviruses, Epstein-Barr virus (EBV) has not yet been shown to infect macrophages. Six macrophage cultures were isolated from normal and affected samples. Nested polymerase chain reaction revealed the existence of the EBV genome in all these macrophages. EBV latent genes expression in all cultures were detected by mRNA in situ hybridization and immunofluorescence staining. Some cultures also expressed EBV replicative-infection proteins, while in other cultures induction of these proteins was demonstrated. These findings are the first to show expression of several latent and replicative-infection genes of EBV in macrophages, indicating that EBV proliferates in macrophages.

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Year:  1999        PMID： 10076516     DOI： 10.1007/s007050050492

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  14 in total

1.  Infection of primary human monocytes by Epstein-Barr virus.

Authors:  M Savard; C Bélanger; M Tardif; P Gourde; L Flamand; J Gosselin
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

2.  Macrophage involvement in Epstein-Barr virus-related tumors.

Authors:  Misuzu Shimakage; Haruhiko Sakamoto
Journal:  Exp Ther Med       Date:  2010-03-01       Impact factor: 2.447

3.  Epstein-Barr virus (EBV)-infected monocytes facilitate dissemination of EBV within the oral mucosal epithelium.

Authors:  Sharof Tugizov; Rossana Herrera; Piri Veluppillai; John Greenspan; Deborah Greenspan; Joel M Palefsky
Journal:  J Virol       Date:  2007-03-21       Impact factor: 5.103

Review 4.  Gammaherpesviruses and B Cells: A Relationship That Lasts a Lifetime.

Authors:  Kaitlin E Johnson; Vera L Tarakanova
Journal:  Viral Immunol       Date:  2020-01-08       Impact factor: 2.257

5.  LXR Alpha Restricts Gammaherpesvirus Reactivation from Latently Infected Peritoneal Cells.

Authors:  P T Lange; C N Jondle; E J Darrah; K E Johnson; V L Tarakanova
Journal:  J Virol       Date:  2019-03-05       Impact factor: 5.103

6.  A replication-defective gammaherpesvirus efficiently establishes long-term latency in macrophages but not in B cells in vivo.

Authors:  Haiyan Li; Kazufumi Ikuta; John W Sixbey; Scott A Tibbetts
Journal:  J Virol       Date:  2008-06-18       Impact factor: 5.103

7.  Human monocytic cell lines transformed in vitro by Epstein-Barr virus display a type II latency and LMP-1-dependent proliferation.

Authors:  Eric Masy; Eric Adriaenssens; Claire Montpellier; Pascale Crépieux; Alexandra Mougel; Brigitte Quatannens; Gautier Goormachtigh; Nathalie Faumont; Fabienne Meggetto; Claude Auriault; Hervé Groux; Jean Coll
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103

8.  The Epstein-Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cells.

Authors:  Jianqiao Xiao; Joel M Palefsky; Rossana Herrera; Jennifer Berline; Sharof M Tugizov
Journal:  Virology       Date:  2007-10-22       Impact factor: 3.616

9.  Low-Density Lipoprotein Receptor Suppresses the Endogenous Cholesterol Synthesis Pathway To Oppose Gammaherpesvirus Replication in Primary Macrophages.

Authors:  C A Aurubin; D A Knaack; D Sahoo; V L Tarakanova
Journal:  J Virol       Date:  2021-08-10       Impact factor: 5.103

Review 10.  Molecular pathogenesis of B-cell posttransplant lymphoproliferative disorder: what do we know so far?

Authors:  J Morscio; D Dierickx; T Tousseyn
Journal:  Clin Dev Immunol       Date:  2013-04-14
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