OBJECTIVE: We tested the hypothesis that the maternal leptin concentration would be increased in preeclampsia, independent of maternal obesity. STUDY DESIGN: Maternal and cord plasma leptin concentrations were compared in 2 groups of women with either preeclampsia (n = 24) or normal pregnancy (n = 24), matched 1:1 for prepregnancy body mass index and fetal gestational age at sampling. RESULTS: Median leptin concentrations were significantly higher (P <. 03) in women with preeclampsia (45.6 ng/mL) than in normal pregnant women (27.0 ng/mL) and fell rapidly shortly after delivery (26.7 ng/mL and 25.4 ng/mL, respectively). Cord leptin was not significantly different between groups (5.4 ng/mL and 5.8 ng/mL, respectively). Maternal and cord leptin correlated significantly (rho = 0.76, P <.01) only in preeclampsia. CONCLUSION: Preeclampsia is associated with an increase in maternal plasma leptin concentrations that strongly correlates with the fetal cord concentration at delivery.
OBJECTIVE: We tested the hypothesis that the maternal leptin concentration would be increased in preeclampsia, independent of maternal obesity. STUDY DESIGN: Maternal and cord plasma leptin concentrations were compared in 2 groups of women with either preeclampsia (n = 24) or normal pregnancy (n = 24), matched 1:1 for prepregnancy body mass index and fetal gestational age at sampling. RESULTS: Median leptin concentrations were significantly higher (P <. 03) in women with preeclampsia (45.6 ng/mL) than in normal pregnant women (27.0 ng/mL) and fell rapidly shortly after delivery (26.7 ng/mL and 25.4 ng/mL, respectively). Cord leptin was not significantly different between groups (5.4 ng/mL and 5.8 ng/mL, respectively). Maternal and cord leptin correlated significantly (rho = 0.76, P <.01) only in preeclampsia. CONCLUSION: Preeclampsia is associated with an increase in maternal plasma leptin concentrations that strongly correlates with the fetal cord concentration at delivery.
Authors: Virginia D Winn; Matthew Gormley; Agnes C Paquet; Kasper Kjaer-Sorensen; Anita Kramer; Kristen K Rumer; Ronit Haimov-Kochman; Ru-Fang Yeh; Michael T Overgaard; Ajit Varki; Claus Oxvig; Susan J Fisher Journal: Endocrinology Date: 2008-09-25 Impact factor: 4.736
Authors: S Aydin; S P Guzel; S Kumru; Suna Aydin; O Akin; E Kavak; I Sahin; M Bozkurt; I Halifeoglu Journal: J Physiol Biochem Date: 2008-03 Impact factor: 4.158
Authors: Shali Mazaki-Tovi; Adi L Tarca; Edi Vaisbuch; Juan Pedro Kusanovic; Nandor Gabor Than; Tinnakorn Chaiworapongsa; Zhong Dong; Sonia S Hassan; Roberto Romero Journal: J Perinat Med Date: 2016-10-01 Impact factor: 1.901