| Literature DB >> 10075801 |
P Cai1, D Smith, B Cunningham, S Brown-Shimer, B Katz, C Pearce, D Venables, D Houck.
Abstract
In the course of screening for small-molecule modulators of erythropoietin gene expression, a novel N-hydroxy pyridone was isolated from a culture of OS-F61800. Its structure was elucidated by extensive 1H and 13C NMR spectroscopic and chemical studies. This compound induced erythropoietin gene expression fivefold at a concentration of 0.3 microM, which is about threefold greater potency than our previously identified erythropoietin inducers.Entities:
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Year: 1999 PMID： 10075801 DOI： 10.1021/np980450t
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050