Literature DB >> 10075775

Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens.

J Neve1, P A Leone, A R Carroll, R W Moni, N J Paczkowski, G Pierens, P Björquist, J Deinum, J Ehnebom, T Inghardt, G Guymer, P Grimshaw, R J Quinn.   

Abstract

Sideroxylonal C (3), a new phloroglucinol dimer, was isolated from the flowers of Eucalyptus albens through bioassay-guided fractionation. The structure elucidation was based on 1D and 2D NMR experiments, MS analysis, and comparison with sideroxylonals A (1) and B (2). Sideroxylonal C inhibited human plasminogen activator inhibitor type-1 at 4.7 microM without any significant effect on human tissue plasminogen activator.

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Year:  1999        PMID: 10075775     DOI: 10.1021/np980286+

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  7 in total

1.  Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1.

Authors:  Jacqueline M Cale; Shih-Hon Li; Mark Warnock; Enming J Su; Paul R North; Karen L Sanders; Maria M Puscau; Cory D Emal; Daniel A Lawrence
Journal:  J Biol Chem       Date:  2010-01-08       Impact factor: 5.157

Review 2.  Is it time for artificial intelligence to predict the function of natural products based on 2D-structure.

Authors:  Miaomiao Liu; Peter Karuso; Yunjiang Feng; Esther Kellenberger; Fei Liu; Can Wang; Ronald J Quinn
Journal:  Medchemcomm       Date:  2019-06-06       Impact factor: 3.597

Review 3.  Plasminogen activator inhibitor type-1 (part two): role for failure of thrombolytic therapy. PAI-1 resistance as a potential benefit for new fibrinolytic agents.

Authors:  K Huber
Journal:  J Thromb Thrombolysis       Date:  2001-05       Impact factor: 2.300

4.  Jensenone: biological reactivity of a marsupial antifeedant from Eucalyptus.

Authors:  Stuart McLean; Sue Brandon; Noel W Davies; William J Foley; H Konrad Muller
Journal:  J Chem Ecol       Date:  2004-01       Impact factor: 2.626

5.  Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1.

Authors:  Shih-Hon Li; Ashley A Reinke; Karen L Sanders; Cory D Emal; James C Whisstock; Jeanne A Stuckey; Daniel A Lawrence
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-02       Impact factor: 11.205

6.  Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1.

Authors:  Anja P Einholm; Katrine E Pedersen; Troels Wind; Paulina Kulig; Michael T Overgaard; Jan K Jensen; Julie S Bødker; Anni Christensen; Peter Charlton; Peter A Andreasen
Journal:  Biochem J       Date:  2003-08-01       Impact factor: 3.857

7.  Quantification and Localization of Formylated Phloroglucinol Compounds (FPCs) in Eucalyptus Species.

Authors:  Bruna Marques Dos Santos; Juliane F S Zibrandtsen; Disan Gunbilig; Mette Sørensen; Federico Cozzi; Berin A Boughton; Allison Maree Heskes; Elizabeth Heather Jakobsen Neilson
Journal:  Front Plant Sci       Date:  2019-02-26       Impact factor: 5.753

  7 in total

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