Literature DB >> 10075746

New cytotoxic oxygenated fucosterols from the brown alga Turbinaria conoides.

J H Sheu1, G H Wang, P J Sung, C Y Duh.   

Abstract

Fucosterol (1), 24xi-hydroperoxy-24-vinylcholesterol (2), 29-hydroperoxystigmasta-5,24(28)-dien-3beta-ol (3), 24-ethylcholesta-4,24(28)-dien-3-one (4), 24xi-hydroperoxy-24-ethylcholesta-4,28(29)-dien-3-one (5), 24-ethylcholesta-4,24(28)-dien-3,6-dione (6), 24xi-hydroperoxy-24-ethylcholesta-4,28(29)-dien-3,6-di one (7), 6beta-hydroxy-24-ethylcholesta-4,24(28)-dien-3-one (8), and 24xi-hydroperoxy-6beta-hydroxy-24-ethylcholesta-4,28(2 9)-dien-3-one (9) were isolated from the marine brown alga Turbinaria conoides. The structures of these compounds were established by spectral analysis. Isolated for the first time from a natural source, the oxygenated fucosterols 4-9 exhibit cytotoxicity against various cancer cell lines.

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Year:  1999        PMID： 10075746     DOI： 10.1021/np980233s

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

1.  Acute toxicity study and antipyretic effect of the brown alga Turbinaria conoides (J. Agardh) Kuetz.

Authors:  S Sadish Kumar; Y Kumar; M S Y Khan; J Anbu; K G Sam
Journal:  Afr J Tradit Complement Altern Med       Date:  2009-05-07

2.  In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts.

Authors:  Souleymane Fofana; Cédric Delporte; Rafaèle Calvo Esposito; Moussa Ouédraogo; Pierre Van Antwerpen; Innocent Pierre Guissou; Rasmané Semdé; Véronique Mathieu
Journal:  Molecules       Date:  2022-04-16       Impact factor: 4.927

3.  Antiproliferative compounds of Helmiopsis sphaerocarpa from the Madagascar rainforest.

Authors:  Shugeng Cao; Peggy Brodie; James S Miller; Chris Birkinshaw; A Rakotondrafara; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal:  Nat Prod Res       Date:  2009       Impact factor: 2.861

Review 4.  Advances in Microalgae-Derived Phytosterols for Functional Food and Pharmaceutical Applications.

Authors:  Xuan Luo; Peng Su; Wei Zhang
Journal:  Mar Drugs       Date:  2015-07-09       Impact factor: 5.118

5.  Antimicrobial and cytotoxic activities of turbinariaconoides (j.agardh) kuetz.

Authors:  Sadish Kumar Shanmugam; Yatendra Kumar; Khan Mohammad Sardaryar; Vivek Gupta; Erik De Clercq
Journal:  Iran J Pharm Res       Date:  2010       Impact factor: 1.696

6.  Bioactive chemical constituents from the brown alga Homoeostrichus formosana.

Authors:  Hui-Yu Fang; Uvarani Chokkalingam; Shu-Fen Chiou; Tsong-Long Hwang; Shu-Li Chen; Wei-Lung Wang; Jyh-Horng Sheu
Journal:  Int J Mol Sci       Date:  2014-12-30       Impact factor: 5.923

7.  Fucosterol Suppresses the Progression of Human Ovarian Cancer by Inducing Mitochondrial Dysfunction and Endoplasmic Reticulum Stress.

Authors:  Hyocheol Bae; Jin-Young Lee; Gwonhwa Song; Whasun Lim
Journal:  Mar Drugs       Date:  2020-05-16       Impact factor: 5.118

8.  Biological importance of marine algae.

Authors:  Ali A El Gamal
Journal:  Saudi Pharm J       Date:  2010-01       Impact factor: 4.330

9.  Spatial and seasonal variations in the biofunctional lipid substances (fucoxanthin and fucosterol) of the laboratory-grown edible Japanese seaweed (Sargassum horneri Turner) cultured in the open sea.

Authors:  Masaru Terasaki; Chikara Kawagoe; Atsushi Ito; Hiroko Kumon; Bhaskar Narayan; Masashi Hosokawa; Kazuo Miyashita
Journal:  Saudi J Biol Sci       Date:  2016-01-11       Impact factor: 4.219

10.  Standardized Fraction of Turbinaria ornata Alleviates Dextran Sulfate Sodium-Induced Chronic Colitis in C57BL/6 Mice via Upregulation of FOXP3+ Regulatory T Cells.

Authors:  Na-Hyun Kim; Seon Min Lee; Yun Na Kim; You-Jin Jeon; Jeong-Doo Heo; Eun Ju Jeong; Jung-Rae Rho
Journal:  Biomolecules       Date:  2020-10-20
  10 in total

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