BACKGROUND: It is estimated that 60% of pregnant women worldwide are anemic. OBJECTIVE: We aimed to examine the influence of iron status on iron absorption during pregnancy by measuring supplemental iron absorption, red blood cell iron incorporation, and iron status in pregnant women. DESIGN: Subjects were 45 pregnant Peruvian women (33+/-1 wk gestation), of whom 28 received daily prenatal supplements containing 60 mg Fe and 250 microg folate without (Fe group, n = 14) or with (Fe+Zn group, n = 14) 15 mg Zn, which were were consumed from week 10 to 24 of gestation until delivery. The remaining 17 women (control) received no prenatal supplementation. Iron status indicators and isotopes were measured in maternal blood collected 2 wk postdosing with oral (57Fe) and intravenous (58Fe) stable iron isotopes. RESULTS: Maternal serum ferritin and folate concentrations were significantly influenced by supplementation (P < 0.05). Serum iron was also significantly higher in the Fe than in the Fe+Zn (P < 0.03) or control (P < 0.001) groups. However, the supplemented groups had significantly lower serum zinc concentrations than the control group (8.4+/-2.3 and 10.9+/-1.8 micromol/L, respectively, P < 0.01). Although percentage iron absorption was inversely related to maternal serum ferritin concentrations (P = 0.036), this effect was limited and percentage iron absorption did not differ significantly between groups. CONCLUSIONS: Because absorption of nonheme iron was not substantially greater in pregnant women with depleted iron reserves, prenatal iron supplementation is important for meeting iron requirements during pregnancy.
BACKGROUND: It is estimated that 60% of pregnant women worldwide are anemic. OBJECTIVE: We aimed to examine the influence of iron status on iron absorption during pregnancy by measuring supplemental iron absorption, red blood cell iron incorporation, and iron status in pregnant women. DESIGN: Subjects were 45 pregnant Peruvian women (33+/-1 wk gestation), of whom 28 received daily prenatal supplements containing 60 mg Fe and 250 microg folate without (Fe group, n = 14) or with (Fe+Zn group, n = 14) 15 mg Zn, which were were consumed from week 10 to 24 of gestation until delivery. The remaining 17 women (control) received no prenatal supplementation. Iron status indicators and isotopes were measured in maternal blood collected 2 wk postdosing with oral (57Fe) and intravenous (58Fe) stable iron isotopes. RESULTS: Maternal serum ferritin and folate concentrations were significantly influenced by supplementation (P < 0.05). Serum iron was also significantly higher in the Fe than in the Fe+Zn (P < 0.03) or control (P < 0.001) groups. However, the supplemented groups had significantly lower serum zinc concentrations than the control group (8.4+/-2.3 and 10.9+/-1.8 micromol/L, respectively, P < 0.01). Although percentage iron absorption was inversely related to maternal serum ferritin concentrations (P = 0.036), this effect was limited and percentage iron absorption did not differ significantly between groups. CONCLUSIONS: Because absorption of nonheme iron was not substantially greater in pregnant women with depleted iron reserves, prenatal iron supplementation is important for meeting iron requirements during pregnancy.
Entities:
Keywords:
Americas; Anemia--prevention and control; Biology; Delivery Of Health Care; Demographic Factors; Developing Countries; Diseases; Food Supplementation; Health; Health Services; Iron; Latin America; Metals; Micronutrients; Nutrition Programs; Peru; Physiology; Population; Population Characteristics; Pregnancy; Pregnant Women; Primary Health Care; Reproduction; Research Report; South America
Authors: Ramadhani A Noor; Ajibola I Abioye; Anne Marie Darling; Ellen Hertzmark; Said Aboud; Zulfiqarali Premji; Ferdinand M Mugusi; Christopher Duggan; Christopher R Sudfeld; Donna Spiegelman; Wafaie Fawzi Journal: J Nutr Date: 2020-02-01 Impact factor: 4.798
Authors: Melissa F Young; Ian Griffin; Eva Pressman; Allison W McIntyre; Elizabeth Cooper; Thomas McNanley; Z Leah Harris; Mark Westerman; Kimberly O O'Brien Journal: J Nutr Date: 2011-11-23 Impact factor: 4.798
Authors: Melissa F Young; Ian Griffin; Eva Pressman; Allison W McIntyre; Elizabeth Cooper; Thomas McNanley; Z Leah Harris; Mark Westerman; Kimberly O O'Brien Journal: J Nutr Date: 2010-10-27 Impact factor: 4.798
Authors: Krishnapillai Madhavan Nair; Ginnela N V Brahmam; Madhari S Radhika; Roy Choudhury Dripta; Punjal Ravinder; Nagalla Balakrishna; Zhensheng Chen; Keli M Hawthorne; Steven A Abrams Journal: J Nutr Date: 2013-04-17 Impact factor: 4.798