OBJECTIVE: To define the evoked potential responses (auditory and somatosensory) obtained from pediatric brain-dead patients. DESIGN: Prospective study over an 8-yr period (1988-1996). SETTING: A 14-bed pediatric intensive care unit in a multidisciplinary regional referral center (teaching hospital). PATIENTS: Fifty-one pediatric patients with clinically established brain death. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Auditory brainstem and somatosensory evoked potentials were performed with a mean evolution time of 24 hrs after clinical brain death. The first brainstem auditory evoked potential recording was compatible with the diagnosis in 45 patients (90%): 27 patients (53%) did not respond, wave I was patent in 16 (7 bilateral, 6 from the left side, and 3 from the right side), and 2 patients evoked waves I and II in one or both ears. Gross anomalies were found in the remaining six patients. Sixteen patients were tested for somatosensory evoked potentials. N13 identifiable wave (62.5% of the patients) or a flat record were the obtained findings. Electric silence was noted initially on the electroencephalogram (EEG) in only 14 of 29 patients. Later flattening was observed in seven patients. Missing brainstem evoked response was noted earlier than cortical electric silence (range, 12-144 hrs). Any central wave could be pointed out in the evoked potentials of patients with an isoelectric EEG. CONCLUSIONS: Evoked potential is useful in confirming the diagnosis of brain death in infants and in children as well as in adults. The test can be performed at bedside without interfering with patient care, and results are similar to those obtained in adult patients. Flattening of the EEG requires more time than achieving compatible evoked-potential responses.
OBJECTIVE: To define the evoked potential responses (auditory and somatosensory) obtained from pediatric brain-dead patients. DESIGN: Prospective study over an 8-yr period (1988-1996). SETTING: A 14-bed pediatric intensive care unit in a multidisciplinary regional referral center (teaching hospital). PATIENTS: Fifty-one pediatric patients with clinically established brain death. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Auditory brainstem and somatosensory evoked potentials were performed with a mean evolution time of 24 hrs after clinical brain death. The first brainstem auditory evoked potential recording was compatible with the diagnosis in 45 patients (90%): 27 patients (53%) did not respond, wave I was patent in 16 (7 bilateral, 6 from the left side, and 3 from the right side), and 2 patients evoked waves I and II in one or both ears. Gross anomalies were found in the remaining six patients. Sixteen patients were tested for somatosensory evoked potentials. N13 identifiable wave (62.5% of the patients) or a flat record were the obtained findings. Electric silence was noted initially on the electroencephalogram (EEG) in only 14 of 29 patients. Later flattening was observed in seven patients. Missing brainstem evoked response was noted earlier than cortical electric silence (range, 12-144 hrs). Any central wave could be pointed out in the evoked potentials of patients with an isoelectric EEG. CONCLUSIONS: Evoked potential is useful in confirming the diagnosis of brain death in infants and in children as well as in adults. The test can be performed at bedside without interfering with patient care, and results are similar to those obtained in adult patients. Flattening of the EEG requires more time than achieving compatible evoked-potential responses.