Literature DB >> 10074470

How Taxol stabilises microtubule structure.

L A Amos1, J Löwe.   

Abstract

The structure of tubulin shows paclitaxel (Taxol(R)) binding to a pocket in beta tubulin on the microtubule's inner surface, which counteracts the effects of GTP hydrolysis occurring on the other side of the monomer.

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Year:  1999        PMID： 10074470     DOI： 10.1016/s1074-5521(99)89002-4

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  72 in total

Review 1.  Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain.

Authors:  Marco Sisignano; Ralf Baron; Klaus Scholich; Gerd Geisslinger
Journal:  Nat Rev Neurol       Date:  2014-11-04       Impact factor: 42.937

2.  Modulation of microtubule interprotofilament interactions by modified taxanes.

Authors:  Ruth Matesanz; Javier Rodríguez-Salarichs; Benet Pera; Angeles Canales; José Manuel Andreu; Jesús Jiménez-Barbero; Wim Bras; Aurora Nogales; Wei-Shuo Fang; José Fernando Díaz
Journal:  Biophys J       Date:  2011-12-20       Impact factor: 4.033

3.  Paclitaxel and TRAIL synergize to kill paclitaxel-resistant small cell lung cancer cells through a caspase-independent mechanism mediated through AIF.

Authors:  Terri B Hunter; Neil J Manimala; Kimberly A Luddy; Tracy Catlin; Scott J Antonia
Journal:  Anticancer Res       Date:  2011-10       Impact factor: 2.480

4.  Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.

Authors:  Jessica J Field; Benet Pera; Enrique Calvo; Angeles Canales; Didier Zurwerra; Chiara Trigili; Javier Rodríguez-Salarichs; Ruth Matesanz; Arun Kanakkanthara; St John Wakefield; A Jonathan Singh; Jesús Jiménez-Barbero; Peter Northcote; John H Miller; Juan Antonio López; Ernest Hamel; Isabel Barasoain; Karl-Heinz Altmann; José Fernando Díaz
Journal:  Chem Biol       Date:  2012-06-22

5.  Radial compression of microtubules and the mechanism of action of taxol and associated proteins.

Authors:  Daniel J Needleman; Miguel A Ojeda-Lopez; Uri Raviv; Kai Ewert; Herbert P Miller; Leslie Wilson; Cyrus R Safinya
Journal:  Biophys J       Date:  2005-08-12       Impact factor: 4.033

6.  Elastic response, buckling, and instability of microtubules under radial indentation.

Authors:  Iwan A T Schaap; Carolina Carrasco; Pedro J de Pablo; Frederick C MacKintosh; Christoph F Schmidt
Journal:  Biophys J       Date:  2006-05-26       Impact factor: 4.033

7.  Microtubule stability studied by three-dimensional molecular theory of solvation.

Authors:  Piotr Drabik; Sergey Gusarov; Andriy Kovalenko
Journal:  Biophys J       Date:  2006-10-20       Impact factor: 4.033

Review 8.  Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease.

Authors:  Kurt R Brunden; John Q Trojanowski; Amos B Smith; Virginia M-Y Lee; Carlo Ballatore
Journal:  Bioorg Med Chem       Date:  2013-12-30       Impact factor: 3.641

9.  Relating molecular flexibility to function: a case study of tubulin.

Authors:  Ozlem Keskin; Stewart R Durell; Ivet Bahar; Robert L Jernigan; David G Covell
Journal:  Biophys J       Date:  2002-08       Impact factor: 4.033

10.  Novel mutations involving βI-, βIIA-, or βIVB-tubulin isotypes with functional resemblance to βIII-tubulin in breast cancer.

Authors:  Weiwei Wang; Hangxiao Zhang; Xumin Wang; Jordan Patterson; Philip Winter; Kathryn Graham; Sunita Ghosh; John C Lee; Christos D Katsetos; John R Mackey; Jack A Tuszynski; Gane Ka-Shu Wong; Richard F Ludueña
Journal:  Protoplasma       Date:  2016-12-09       Impact factor: 3.356
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