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Literature DB >> 10074094

A missense mutation accounts for the defect in the glycerol-3-phosphate acyltransferase expressed in the plsB26 mutant.

Abstract

The sn-glycerol-3-phosphate acyltransferase (plsB) catalyzes the first step in membrane phospholipid formation. A conditional Escherichia coli mutant (plsB26) has a single missense mutation (G1045A) predicting the expression of an acyltransferase with an Ala349Thr substitution. The PlsB26 protein had a significantly reduced glycerol-3-phosphate acyltransferase specific activity coupled with an elevated Km for glycerol-3-phosphate.

Entities: Chemical Gene Mutation Species

Mesh：

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Year: 1999 PMID： 10074094 PMCID： PMC93600

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

14 in total

1. Mutants of Escherichia coli defective in membrane phospholipid synthesis. Properties of wild type and Km defective sn-glycerol-3-phosphate acyltransferase activities.

Authors: R M Bell
Journal: J Biol Chem Date: 1975-09-25 Impact factor: 5.157

2. Mutants of Escherichia coli defective in membrane phospholipid synthesis. Phenotypic suppression of sn-glycerol-3-phosphate acyltransferase Km mutants by loss of feedback inhibition of the biosynthetic sn-glycerol-3-phosphate dehydrogenase.

Authors: R M Bell; J E Cronan
Journal: J Biol Chem Date: 1975-09-25 Impact factor: 5.157

3. A conserved histidine is essential for glycerolipid acyltransferase catalysis.

Authors: R J Heath; C O Rock
Journal: J Bacteriol Date: 1998-03 Impact factor: 3.490

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Authors: C R Raetz
Journal: Microbiol Rev Date: 1978-09

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Authors: C O Rock; S E Goelz; J E Cronan
Journal: Arch Biochem Biophys Date: 1981-10-01 Impact factor: 4.013

6. Membrane phospholipid synthesis in Escherichia coli. Cloning of a structural gene (plsB) of the sn-glycerol-3-phosphate acyl/transferase.

Authors: V A Lightner; T J Larson; P Tailleur; G D Kantor; C R Raetz; R M Bell; P Modrich
Journal: J Biol Chem Date: 1980-10-10 Impact factor: 5.157

7. sn-Glycerol-3-phosphate auxotrophy of plsB strains of Escherichia coli: evidence that a second mutation, plsX, is required.

Authors: T J Larson; D N Ludtke; R M Bell
Journal: J Bacteriol Date: 1984-11 Impact factor: 3.490

8. Regulation of phospholipid synthesis in Escherichia coli. Composition of the acyl-acyl carrier protein pool in vivo.

Authors: C O Rock; S Jackowski
Journal: J Biol Chem Date: 1982-09-25 Impact factor: 5.157

9. Mutants of Escherichia coli defective in membrane phospholipid synthesis: macromolecular synthesis in an sn-glycerol 3-phosphate acyltransferase Km mutant.

Authors: R M Bell
Journal: J Bacteriol Date: 1974-03 Impact factor: 3.490

10. Mutants of Escherichia coli defective in membrane phospholipid synthesis: mapping of sn-glycerol 3-phosphate acyltransferase Km mutants.

Authors: J E Cronan; R M Bell
Journal: J Bacteriol Date: 1974-10 Impact factor: 3.490

7 in total

1. GlpD and PlsB participate in persister cell formation in Escherichia coli.

Authors: Amy L Spoering; Marin Vulic; Kim Lewis
Journal: J Bacteriol Date: 2006-07 Impact factor: 3.490

2. Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium.

Authors: Anne P Beigneux; Laurent Vergnes; Xin Qiao; Steven Quatela; Ryan Davis; Steven M Watkins; Rosalind A Coleman; Rosemary L Walzem; Mark Philips; Karen Reue; Stephen G Young
Journal: J Lipid Res Date: 2006-01-31 Impact factor: 5.922

Review 3. Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis.

Authors: Angela A Wendel; Tal M Lewin; Rosalind A Coleman
Journal: Biochim Biophys Acta Date: 2008-11-07

4. Coupling of fatty acid and phospholipid synthesis in Bacillus subtilis.

Authors: Luciana Paoletti; Ying-Jie Lu; Gustavo E Schujman; Diego de Mendoza; Charles O Rock
Journal: J Bacteriol Date: 2007-06-08 Impact factor: 3.490

Review 5. Bacterial lipids: metabolism and membrane homeostasis.

Authors: Joshua B Parsons; Charles O Rock
Journal: Prog Lipid Res Date: 2013-03-14 Impact factor: 16.195

6. Involvement of the YneS/YgiH and PlsX proteins in phospholipid biosynthesis in both Bacillus subtilis and Escherichia coli.

Authors: Mika Yoshimura; Taku Oshima; Naotake Ogasawara
Journal: BMC Microbiol Date: 2007-07-24 Impact factor: 3.605

7. Potential use of sugar binding proteins in reactors for regeneration of CO2 fixation acceptor D-Ribulose-1,5-bisphosphate.

Authors: Sourav Mahato; Debojyoti De; Debajyoti Dutta; Moloy Kundu; Sumana Bhattacharya; Marc T Schiavone; Sanjoy K Bhattacharya
Journal: Microb Cell Fact Date: 2004-06-02 Impact factor: 5.328

7 in total