Literature DB >> 10072358

Telomere maintenance mechanisms and cellular immortalization.

L M Colgin1, R R Reddel.   

Abstract

Immortal cell populations are able to proliferate indefinitely. Immortalization is associated with activation of processes that compensate for the telomeric shortening that accompanies cell division in normal somatic cells. In many immortal cell lines, telomere maintenance is provided by the action of the ribonucleoprotein enzyme complex, telomerase. Some immortal cell lines have undetectable or very low levels of telomerase activity and there is evidence that these cells maintain their telomeres by an alternative mechanism.

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Year:  1999        PMID： 10072358     DOI： 10.1016/s0959-437x(99)80014-8

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  42 in total

1.  Telomerase reverse transcriptase expression is increased early in the Barrett's metaplasia, dysplasia, adenocarcinoma sequence.

Authors:  R V Lord; D Salonga; K D Danenberg; J H Peters; T R DeMeester; J M Park; J Johansson; K A Skinner; P Chandrasoma; S R DeMeester; C G Bremner; P I Tsai; P V Danenberg
Journal:  J Gastrointest Surg       Date:  2000 Mar-Apr       Impact factor: 3.452

2.  The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity.

Authors:  L M Colgin; C Wilkinson; A Englezou; A Kilian; M O Robinson; R R Reddel
Journal:  Neoplasia       Date:  2000 Sep-Oct       Impact factor: 5.715

3.  Telomerase activation by human papillomavirus type 16 E6 protein: induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sites.

Authors:  S T Oh; S Kyo; L A Laimins
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

4.  Heterocyclic dications as a new class of telomeric G-quadruplex targeting agents.

Authors:  Rupesh Nanjunda; Caterina Musetti; Arvind Kumar; Mohamed A Ismail; Abdelbasset A Farahat; Siming Wang; Claudia Sissi; Manlio Palumbo; David W Boykin; W David Wilson
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

5.  Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.

Authors:  Anthony J Cesare; Zeenia Kaul; Scott B Cohen; Christine E Napier; Hilda A Pickett; Axel A Neumann; Roger R Reddel
Journal:  Nat Struct Mol Biol       Date:  2009-11-22       Impact factor: 15.369

Review 6.  Dyskeratosis congenita: a disorder of defective telomere maintenance?

Authors:  Amanda J Walne; Anna Marrone; Inderjeet Dokal
Journal:  Int J Hematol       Date:  2005-10       Impact factor: 2.490

7.  Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA.

Authors:  M S Fitzgerald; K Riha; F Gao; S Ren; T D McKnight; D E Shippen
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

8.  Short rare hTERT-VNTR2-2nd alleles are associated with prostate cancer susceptibility and influence gene expression.

Authors:  Se-Lyun Yoon; Se-Il Jung; Eun-Ju Do; Se-Ra Lee; Sang-Yeop Lee; In-Sun Chu; Wun-Jae Kim; Jaeil Jung; Choung Soo Kim; Sang-Hyeon Cheon; Sun-Hee Leem
Journal:  BMC Cancer       Date:  2010-07-26       Impact factor: 4.430

9.  Biochemical properties of Trypanosoma cruzi telomerase.

Authors:  Denise P Muñoz; Kathleen Collins
Journal:  Nucleic Acids Res       Date:  2004-09-30       Impact factor: 16.971

10.  Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes.

Authors:  Tanja Deurholt; Niek P van Til; Aniska A Chhatta; Lysbeth ten Bloemendaal; Ruth Schwartlander; Catherine Payne; John N Plevris; Igor M Sauer; Robert Afm Chamuleau; Ronald Pj Oude Elferink; Jurgen Seppen; Ruurdtje Hoekstra
Journal:  BMC Biotechnol       Date:  2009-10-21       Impact factor: 2.563
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