| Literature DB >> 10072317 |
B A Horwitz1, A Sharon, S W Lu, V Ritter, T M Sandrock, O C Yoder, B G Turgeon.
Abstract
A Galpha subunit-encoding gene (CGA1) was cloned from Cochliobolus heterostrophus, a heterothallic foliar pathogen of corn. The deduced amino acid sequence showed similarity to Galpha proteins from other filamentous fungi and suggested that CGA1 is a member of the Galphai class. cga1 mutants had reduced ability to form appressoria on glass surfaces and on corn leaves; mutants nevertheless caused lesions on corn plants like those of wild type. cga1 mutants were female sterile; sexual development was completely abolished when the mutant allele was homozygous in a cross. Ascospores produced in crosses heterozygous at Cga1 were all wild type. The signal transduction pathway represented by CGA1 appears to be involved in developmental pathways leading to either appressorium formation or mating; in sexual development CGA1 is required for both fertility and ascospore viability. Copyright 1999 Academic Press.Entities:
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Year: 1999 PMID： 10072317 DOI： 10.1006/fgbi.1998.1094
Source DB: PubMed Journal: Fungal Genet Biol ISSN： 1087-1845 Impact factor: 3.495