C H Kao1, Y Y Shen, J K Lee. 1. Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China. kao@vghtc.vghtc.gov.tw
Abstract
BACKGROUND: To determine the influence of smoking on 99mTc-labeled methoxyisobutylisonitrile (99mTc-MIBI) lung uptake during myocardial perfusion imaging, we examined 60 subjects with normal myocardial perfusion scans, normal coronary angiograms, and no evidence of left ventricular hypertrophy. METHODS AND RESULTS: The subjects were divided into 2 groups: Group 1 subjects had smoking histories of at least 10 pack-years and Group 2 subjects were nonsmokers. 99mTc-MIBI lung to heart ratios (L/H ratios) from anterior planar images were obtained for all subjects during exercise and resting states. 99mTc-MIBI L/H ratios in smokers were significantly higher than in nonsmokers in both exercise and resting states. However, no significant difference in L/H ratios was found between exercise and resting states in smokers and nonsmokers. In addition, no significant correlation was found between smoking pack-years and either rest or exercise L/H ratios. CONCLUSIONS: 99mTc-MIBI L/H ratios in smokers are higher than in nonsmokers. This must be considered when 99mTc-MIBI L/H ratios are used clinically.
BACKGROUND: To determine the influence of smoking on 99mTc-labeled methoxyisobutylisonitrile (99mTc-MIBI) lung uptake during myocardial perfusion imaging, we examined 60 subjects with normal myocardial perfusion scans, normal coronary angiograms, and no evidence of left ventricular hypertrophy. METHODS AND RESULTS: The subjects were divided into 2 groups: Group 1 subjects had smoking histories of at least 10 pack-years and Group 2 subjects were nonsmokers. 99mTc-MIBI lung to heart ratios (L/H ratios) from anterior planar images were obtained for all subjects during exercise and resting states. 99mTc-MIBI L/H ratios in smokers were significantly higher than in nonsmokers in both exercise and resting states. However, no significant difference in L/H ratios was found between exercise and resting states in smokers and nonsmokers. In addition, no significant correlation was found between smoking pack-years and either rest or exercise L/H ratios. CONCLUSIONS:99mTc-MIBI L/H ratios in smokers are higher than in nonsmokers. This must be considered when 99mTc-MIBI L/H ratios are used clinically.
Authors: R Giubbini; R Campini; E Milan; O Zoccarato; C Orlandi; P Rossini; P Giannuzzi; G La Canna; M Galli Journal: J Nucl Med Date: 1995-01 Impact factor: 10.057
Authors: F J Wackers; D S Berman; J Maddahi; D D Watson; G A Beller; H W Strauss; C A Boucher; M Picard; B L Holman; R Fridrich Journal: J Nucl Med Date: 1989-03 Impact factor: 10.057