Literature DB >> 10070665

Periodate-sensitive immunological cross-reactivity between keyhole limpet haemocyanin (KLH) and serodiagnostic Schistosoma mansoni egg antigens.

J V Hamilton1, P L Chiodini, P G Fallon, M J Doenhoff.   

Abstract

Both CEF6, a cation-exchange fraction of soluble Schistosoma mansoni egg antigens (SEA), composed of the 2 antigens, alpha-1 and omega-1, and haemocyanin from the keyhole limpet, Megathura crenulata, have shown potential for immunodiagnosis of human schistosomiasis. Possible cross-reactivity between antigens in SEA and keyhole limpet haemocyanin (KLH) was explored by Western immunoblotting and enzyme-linked immunosorbent assay (ELISA) using sera from rabbits immunized with KLH, SEA, CEF6, alpha-1, omega-1, or egg antigen k5. Both immunoassays revealed a high degree of serological cross-reactivity between the schistosome egg antigens and KLH, much of it due to sodium periodate-sensitive epitopes. Cross-reactivity with schistosome antigens with proven diagnostic efficacy may thus, in part, explain the usefulness of KLH for the diagnosis of human schistosomiasis mansoni.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10070665     DOI： 10.1017/s0031182098003461

Source DB:  PubMed          Journal:  Parasitology        ISSN： 0031-1820            Impact factor:   3.234


  8 in total

1.  Fuc(alpha1-->3)GalNAc-: the major antigenic motif of Schistosoma mansoni glycolipids implicated in infection sera and keyhole-limpet haemocyanin cross-reactivity.

Authors:  Sven R Kantelhardt; Manfred Wuhrer; Roger D Dennis; Michael J Doenhoff; Quentin Bickle; Rudolf Geyer
Journal:  Biochem J       Date:  2002-08-15       Impact factor: 3.857

2.  Antigenic cross-reactivity between Schistosoma mansoni and peanut: a role for cross-reactive carbohydrate determinants (CCDs) and implications for the hygiene hypothesis.

Authors:  Joseph E Igetei; Marwa El-Faham; Susan Liddell; Michael J Doenhoff
Journal:  Immunology       Date:  2017-02-15       Impact factor: 7.397

3.  Application of DNA-based diagnostics in detection of schistosomal DNA in early infection and after drug treatment.

Authors:  Cen Wang; Lin Chen; Xuren Yin; Wanquan Hua; Min Hou; Minjun Ji; Chuanxin Yu; Guanling Wu
Journal:  Parasit Vectors       Date:  2011-08-24       Impact factor: 3.876

4.  Performance of pigs kept under different sanitary conditions affected by protein intake and amino acid supplementation.

Authors:  Y van der Meer; A Lammers; A J M Jansman; M M J A Rijnen; W H Hendriks; W J J Gerrits
Journal:  J Anim Sci       Date:  2016-11       Impact factor: 3.159

5.  Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor.

Authors:  Bart Everts; Leonie Hussaarts; Nicole N Driessen; Moniek H J Meevissen; Gabriele Schramm; Alwin J van der Ham; Barbara van der Hoeven; Thomas Scholzen; Sven Burgdorf; Markus Mohrs; Edward J Pearce; Cornelis H Hokke; Helmut Haas; Hermelijn H Smits; Maria Yazdanbakhsh
Journal:  J Exp Med       Date:  2012-09-10       Impact factor: 14.307

6.  Cross-Reactivity between Schistosoma mansoni Antigens and the Latex Allergen Hev b 7: Putative Implication of Cross-Reactive Carbohydrate Determinants (CCDs).

Authors:  Michael J Doenhoff; Marwa El-Faham; Susan Liddell; Heidi R Fuller; Ronald G Stanley; Gabriele Schramm; Joseph E Igetei
Journal:  PLoS One       Date:  2016-07-28       Impact factor: 3.240

7.  The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism.

Authors:  Emily Hams; Rachel Bermingham; Felicity A Wurlod; Andrew E Hogan; Donal O'Shea; Roger J Preston; Hans-Reimer Rodewald; Andrew N J McKenzie; Padraic G Fallon
Journal:  FASEB J       Date:  2015-10-21       Impact factor: 5.191

8.  Antigenic cross-reactivity between Schistosoma mansoni and allergenic invertebrates putatively due to shared glycanic epitopes.

Authors:  Marwa H El-Faham; Fatou Gai; Joseph E Igetei; Sarah Richter; Franco H Falcone; Gabi Schramm; Michael J Doenhoff
Journal:  Sci Rep       Date:  2020-02-25       Impact factor: 4.379
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.