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Literature DB >> 10068907

In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene.

V Pravica¹, A Asderakis, C Perrey, A Hajeer, P J Sinnott, I V Hutchinson.

Abstract

The DNA sequence of the human IFN-gamma gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the association with interferon-gamma (IFN-gamma) production. In vitro production of IFN-gamma showed a significant correlation with the presence of allele #2.

Entities: Gene Species

Mesh：

Substances：
Interferon-gamma

Year: 1999 PMID： 10068907 DOI： 10.1046/j.1365-2370.1999.00122.x

Source DB: PubMed Journal: Eur J Immunogenet ISSN： 0960-7420

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Cited

93 in total

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In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene.

1. Elevated serum interleukin (IL)-12p40 levels in common variable immunodeficiency disease and decreased peripheral blood dendritic cells: analysis of IL-12p40 and interferon-gamma gene.

2. Association of an intragenic microsatellite marker in the CC16 gene with asthma in the Indian population.

3. Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China.

4. 85-kDa cytosolic phospholipase A2 group IValpha gene promoter polymorphisms in patients with severe asthma: a gene expression and case-control study.

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