BACKGROUND: Helicobacter pylori is a recognized gastroduodenal pathogen and H. pylori infection is one of the most common bacterial infections, usually acquired during childhood. However, diabetes mellitus is characterized by an increased susceptibility to infections. METHODS: We compared the prevalence of H. pylori infection as well as cytotoxin-associated gene A-CagA-and vacuolating cytotoxin gene A-VacA-positivity in 103 children and adolescents with type 1 diabetes mellitus and in 236 nondiabetic children. We used a novel Recombinant ImmunoBlot Assay-Strip (RIBA SIA) with individual band for whole H. pylori lysate and recombinant CagA and VacA. RESULTS: H. pylori-positive subjects, both diabetics and controls, were significantly older than negative subjects. In the whole group of diabetic patients the prevalence of each of the three reactivities was higher than in control subjects, reaching significance only for lysate. Only diabetic patients over 12 years of age, with a longer disease duration, had a higher prevalence of positive cases, although not significantly so. CONCLUSIONS: In the first few years of disease, diabetic children do not differ from the nondiabetic population. Subsequently they show an H. pylori seroprevalence tendentially higher than that of controls of the same age. Therefore, H. pylori infection acquired in childhood and lasting several years, could be one of the causes of chronic atrophic gastritis, which is more frequent in longstanding diabetes mellitus.
BACKGROUND:Helicobacter pylori is a recognized gastroduodenal pathogen and H. pyloriinfection is one of the most common bacterial infections, usually acquired during childhood. However, diabetes mellitus is characterized by an increased susceptibility to infections. METHODS: We compared the prevalence of H. pyloriinfection as well as cytotoxin-associated gene A-CagA-and vacuolating cytotoxin gene A-VacA-positivity in 103 children and adolescents with type 1 diabetes mellitus and in 236 nondiabetic children. We used a novel Recombinant ImmunoBlot Assay-Strip (RIBA SIA) with individual band for whole H. pylori lysate and recombinant CagA and VacA. RESULTS:H. pylori-positive subjects, both diabetics and controls, were significantly older than negative subjects. In the whole group of diabeticpatients the prevalence of each of the three reactivities was higher than in control subjects, reaching significance only for lysate. Only diabeticpatients over 12 years of age, with a longer disease duration, had a higher prevalence of positive cases, although not significantly so. CONCLUSIONS: In the first few years of disease, diabeticchildren do not differ from the nondiabetic population. Subsequently they show an H. pylori seroprevalence tendentially higher than that of controls of the same age. Therefore, H. pyloriinfection acquired in childhood and lasting several years, could be one of the causes of chronic atrophic gastritis, which is more frequent in longstanding diabetes mellitus.
Authors: Lucia Pacifico; John F Osborn; Valeria Tromba; Sara Romaggioli; Stefano Bascetta; Claudio Chiesa Journal: World J Gastroenterol Date: 2014-02-14 Impact factor: 5.742
Authors: Paolo A Tomasi; Maria P Dore; Giuseppe Fanciulli; Franca Sanciu; Giuseppe Realdi; Giuseppe Delitala Journal: Dig Dis Sci Date: 2005-02 Impact factor: 3.199
Authors: Thomas Whalley; Garry Dolton; Paul E Brown; Aaron Wall; Linda Wooldridge; Hugo van den Berg; Anna Fuller; Jade R Hopkins; Michael D Crowther; Meriem Attaf; Robin R Knight; David K Cole; Mark Peakman; Andrew K Sewell; Barbara Szomolay Journal: Front Immunol Date: 2020-02-28 Impact factor: 7.561