Literature DB >> 10066669

Restricted isotypic antibody reactivity to hepatitis C virus synthetic peptides in immunocompromised patients.

M Devesa1, A de Saez, G León, F Sirit, C Cosson, H Bermúdez, F Liprandi, O Noya, F H Pujol.   

Abstract

An enzyme immunoassay based on three synthetic peptides from the core, NS4, and NS5 regions of hepatitis C virus allowed the detection of antibodies in 100% of immunocompetent infected patients and in 91% of immunocompromised patients (hemodialysis and hemophiliac patients). Immune impairment seemed to restrict the spectrum of antibody isotypes reacting to the core peptide.

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Year:  1999        PMID： 10066669      PMCID： PMC95702          DOI： 10.1128/CDLI.6.2.279-281.1999

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  23 in total

1.  General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

Authors:  R A Houghten
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

Review 2.  Host defenses and immunologic alterations associated with chronic hemodialysis.

Authors:  S E Goldblum; W P Reed
Journal:  Ann Intern Med       Date:  1980-10       Impact factor: 25.391

3.  Differences in immune response between HCV positive, HIV negative haemophilia A and B patients.

Authors:  K Meijer; W M Smid; S P Verspiek; J W Smit; J van der Meer
Journal:  Thromb Haemost       Date:  1998-01       Impact factor: 5.249

4.  Antigenic regions within the hepatitis C virus envelope 1 and non-structural proteins: identification of an IgG3-restricted recognition site with the envelope 1 protein.

Authors:  M Sällberg; U Rudén; B Wahren; L O Magnius
Journal:  Clin Exp Immunol       Date:  1993-03       Impact factor: 4.330

5.  Immune response to a single peptide containing an immunodominant region of hepatitis C virus core protein: the isotypes and the recognition site.

Authors:  M Sällberg; U Rudén; B Wahren; L O Magnius
Journal:  Immunol Lett       Date:  1992-06       Impact factor: 3.685

6.  Isotype-specific immune response to a single hepatitis C virus core epitope defined by a human monoclonal antibody: diagnostic value and correlation to PCR.

Authors:  K Siemoneit; M da Silva Cardoso; A Wölpl; S Epple; H Wintersinger; K Koerner; B Kubanek
Journal:  Ann Hematol       Date:  1994-09       Impact factor: 3.673

7.  Immune response to an epitope of the NS4 protein of hepatitis C virus in HCV-related disorders.

Authors:  G Longombardo; C Ferri; S Marchi; F Costa; F Lombardini; L Vacri; S Bombardieri; P Migliorini
Journal:  Clin Immunol Immunopathol       Date:  1998-05

8.  Improved serodiagnosis of hepatitis C virus infection with synthetic peptide antigen from capsid protein.

Authors:  B Hosein; C T Fang; M A Popovsky; J Ye; M Zhang; C Y Wang
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205

9.  Immunoresponsiveness in hemophilia: lymphocyte- and phagocyte-mediated functions.

Authors:  S Antonaci; E Jirillo; D Stasi; V De Mitrio; M F La Via; L Bonomo
Journal:  Diagn Clin Immunol       Date:  1988

10.  A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria.

Authors:  M E Patarroyo; R Amador; P Clavijo; A Moreno; F Guzman; P Romero; R Tascon; A Franco; L A Murillo; G Ponton
Journal:  Nature       Date:  1988-03-10       Impact factor: 49.962
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