Literature DB >> 10066510

Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions.

J C Mottram1, D R Brooks, G H Coombs.   

Abstract

Trypanosomes and Leishmania contain an abundance of stage-regulated cysteine proteinases encoded by several gene families. Analysis of parasites rendered defective in cysteine proteinase function, either through genetic manipulation or through the use of specific inhibitors, has revealed roles for the enzymes in parasite virulence, in modulation of the host's immune response and in parasite differentiation.

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Year:  1998        PMID： 10066510     DOI： 10.1016/s1369-5274(98)80065-9

Source DB:  PubMed          Journal:  Curr Opin Microbiol        ISSN： 1369-5274            Impact factor:   7.934


  34 in total

1.  Structural and immunological characteristics of a 28-kilodalton cruzipain-like cysteine protease of Paragonimus westermani expressed in the definitive host stage.

Authors:  D H Yun; J Y Chung; Y B Chung; Y Y Bahk; S Y Kang; Y Kong; S Y Cho
Journal:  Clin Diagn Lab Immunol       Date:  2000-11

2.  Immunomodulatory peptide from cystatin, a natural cysteine protease inhibitor, against leishmaniasis as a model macrophage disease.

Authors:  Snigdha Mukherjee; Anindita Ukil; Pijush K Das
Journal:  Antimicrob Agents Chemother       Date:  2007-03-05       Impact factor: 5.191

3.  Protease expression by microorganisms and its relevance to crucial physiological/pathological events.

Authors:  André Luis Souza Dos Santos
Journal:  World J Biol Chem       Date:  2011-03-26

4.  Aziridine-2,3-dicarboxylates, peptidomimetic cysteine protease inhibitors with antileishmanial activity.

Authors:  Alicia Ponte-Sucre; Radim Vicik; Martina Schultheis; Tanja Schirmeister; Heidrun Moll
Journal:  Antimicrob Agents Chemother       Date:  2006-07       Impact factor: 5.191

5.  Gene expression analysis of wild Leishmania major isolates: identification of genes preferentially expressed in amastigotes.

Authors:  Meriem Ouakad; Mehdi Chenik; Yosser Ben Achour-Chenik; Hechmi Louzir; Koussay Dellagi
Journal:  Parasitol Res       Date:  2006-10-03       Impact factor: 2.289

6.  Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana.

Authors:  S J Sanderson; K G Pollock; J D Hilley; M Meldal; P S Hilaire; M A Juliano; L Juliano; J C Mottram; G H Coombs
Journal:  Biochem J       Date:  2000-04-15       Impact factor: 3.857

7.  Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.

Authors:  P M Selzer; S Pingel; I Hsieh; B Ugele; V J Chan; J C Engel; M Bogyo; D G Russell; J A Sakanari; J H McKerrow
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

8.  Comparative transcript expression analysis of miltefosine-sensitive and miltefosine-resistant Leishmania donovani.

Authors:  Arpita Kulshrestha; Vanila Sharma; Ruchi Singh; Poonam Salotra
Journal:  Parasitol Res       Date:  2014-01-22       Impact factor: 2.289

9.  Identification, purification, and characterization of a secretory serine protease in an Indian strain of Leishmania donovani.

Authors:  Rajdeep Choudhury; Siddhartha Kumar Bhaumik; Tripti De; Tapati Chakraborti
Journal:  Mol Cell Biochem       Date:  2008-06-29       Impact factor: 3.396

10.  Development of a New Antileishmanial Aziridine-2,3-Dicarboxylate-Based Inhibitor with High Selectivity for Parasite Cysteine Proteases.

Authors:  Caroline Schad; Ulrike Baum; Benjamin Frank; Uwe Dietzel; Felix Mattern; Carlos Gomes; Alicia Ponte-Sucre; Heidrun Moll; Uta Schurigt; Tanja Schirmeister
Journal:  Antimicrob Agents Chemother       Date:  2015-11-23       Impact factor: 5.191
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