| Literature DB >> 10065635 |
A Kharazmi1, K Kemp, A Ismail, S Gasim, A Gaafar, J A Kurtzhals, A M El Hassan, T G Theander, M Kemp.
Abstract
In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-gamma response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-gamma production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-gamma and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.Entities:
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Year: 1999 PMID： 10065635 DOI： 10.1016/s0165-2478(98)00132-1
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685