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Literature DB >> 10065373

P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues.

P E Scarborough¹, J Ma, W Qu, D C Zeldin.

Abstract

Historically, there has been intense interest in P450 metabolic oxidation, peroxidation, and reduction of xenobiotics. More recently, there has been a growing appreciation for the role of P450s in the oxidation of lipophilic endobiotics, such as bile acids, fat-soluble vitamins, and eicosanoids. This review details the emerging CYP2J subfamily of P450s and their role as catalysts of arachidonic acid metabolism.

Entities: Chemical Gene

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Year: 1999 PMID： 10065373 DOI： 10.1081/dmr-100101915

Source DB: PubMed Journal: Drug Metab Rev ISSN： 0360-2532 Impact factor: 4.518

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Cited

16 in total

1. CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].

Authors: Michael Zhuo Wang; Janelle Y Saulter; Etsuko Usuki; Yen-Ling Cheung; Michael Hall; Arlene S Bridges; Greg Loewen; Oliver T Parkinson; Chad E Stephens; James L Allen; Darryl C Zeldin; David W Boykin; Richard R Tidwell; Andrew Parkinson; Mary F Paine; James Edwin Hall
Journal: Drug Metab Dispos Date: 2006-09-22 Impact factor: 3.922

2. Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.

Authors: Joan P Graves; Artiom Gruzdev; J Alyce Bradbury; Laura M DeGraff; Huiling Li; John S House; Samantha L Hoopes; Matthew L Edin; Darryl C Zeldin
Journal: Drug Metab Dispos Date: 2015-05-20 Impact factor: 3.922

3. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition.

Authors: Brandon T Larsen; Hiroto Miura; Ossama A Hatoum; William B Campbell; Bruce D Hammock; Darryl C Zeldin; John R Falck; David D Gutterman
Journal: Am J Physiol Heart Circ Physiol Date: 2005-10-28 Impact factor: 4.733

Review 4. Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates diabetes and metabolic syndrome complications.

Authors: Angela Burgess; Luca Vanella; Lars Bellner; Michal L Schwartzman; Nader G Abraham
Journal: Prostaglandins Other Lipid Mediat Date: 2011-11-15 Impact factor: 3.072

P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues.

1. CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].

2. Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.

3. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition.

Review 4. Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates diabetes and metabolic syndrome complications.

5. Molecular cloning and enzymatic characterization of sheep CYP2J.

6. Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney.

7. Phylogenetic and functional analysis of the vertebrate cytochrome p450 2 family.

8. Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.

9. Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.

10. The human intestinal cytochrome P450 "pie".