Literature DB >> 10065345

On the accuracy of a new displacement instrumentation for rotary tablet presses.

C Matz1, A Bauer-Brandl, T Rigassi, R Schubert, D Becker.   

Abstract

The Portable Press Analyzer (PPA; Puuman Oy, Finland), a commercially available instrumentation for rotary tablet presses, was tested for accuracy of determination of force and displacement. The calibration of the force transducers (strain gauges) was tested under a static condition. The calibration of the displacement transducers (plastic film potentiometer) was compared for static and dynamic recordings. Force measurement was found precise (deviation < 1.1%) after alterations in the calibration procedure. Displacement measurement was affected by punch tilting and the application of the transducers. If tilting of punches was not considered, the deviation of displacement measurement from the true value (using steel tablets as a reference) was found up to 110 microns. By modifying the original PPA system by supplementing additional displacement transducers in the adjacent turret positions of the punches and adding a custom electronic device (Tilting Compensation Device), the accuracy of distance measurement was improved to 18.1 microns (+/- 3.64). Furthermore, machine and tooling deformation were recorded and found different under static and dynamic conditions. Correction of punch displacement for elastic deformation therefore should preferably be made from dynamic recordings.

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Year:  1999        PMID: 10065345     DOI: 10.1081/ddc-100102152

Source DB:  PubMed          Journal:  Drug Dev Ind Pharm        ISSN: 0363-9045            Impact factor:   3.225


  4 in total

1.  Effect of particle size and compression force on compaction behavior and derived mathematical parameters of compressibility.

Authors:  Sarsvatkumar Patel; Aditya Mohan Kaushal; Arvind Kumar Bansal
Journal:  Pharm Res       Date:  2006-10-25       Impact factor: 4.200

2.  Effect of particle size on in-die and out-of-die compaction behavior of ranitidine hydrochloride polymorphs.

Authors:  Kailas S Khomane; Arvind K Bansal
Journal:  AAPS PharmSciTech       Date:  2013-07-30       Impact factor: 3.246

3.  Lubrication potential of magnesium stearate studied on instrumented rotary tablet press.

Authors:  Sarsvatkumar Patel; Aditya Mohan Kaushal; Arvind Kumar Bansal
Journal:  AAPS PharmSciTech       Date:  2007-10-26       Impact factor: 3.246

4.  The 3-D model: comparison of parameters obtained from and by simulating different tableting machines.

Authors:  Katharina M Picker
Journal:  AAPS PharmSciTech       Date:  2003       Impact factor: 3.246

  4 in total

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