Literature DB >> 10064379

Blood and urinary levels of ethanol, acetaldehyde, and C4 compounds such as diacetyl, acetoin, and 2,3-butanediol in normal male students after ethanol ingestion.

M Otsuka1, N Harada, T Itabashi, S Ohmori.   

Abstract

Aldehyde dehydrogenase (ALDH) isozyme 2 genes were determined in 15 students. Of these subjects, five healthy male students were administered 0.4 kg/kg ethanol. One subject was defective in aldehyde dehydrogenase 2 (ALDH2), two had normal ALDH2, and the other two were hetero type. After the intake of alcohol, the concentration of ethanol, acetaldehyde, and C4 compounds in blood and urine were determined. The student with the inactive form of ALDH2 was flushed and his levels of 2,3-butanediol and acetaldehyde in blood and urine were found to be the highest.

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Year:  1999        PMID： 10064379     DOI： 10.1016/s0741-8329(98)00042-1

Source DB:  PubMed          Journal:  Alcohol        ISSN： 0741-8329            Impact factor:   2.405


  5 in total

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Authors:  Timothy R Fennell; Daniel L Morgan; Scott L Watson; Suraj Dhungana; Suramya Waidyanatha
Journal:  Chem Biol Interact       Date:  2015-01-02       Impact factor: 5.192

2.  Breath gas metabolites and bacterial metagenomes from cystic fibrosis airways indicate active pH neutral 2,3-butanedione fermentation.

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3.  Genetic polymorphisms may explain association between alcohol consumption and bladder cancer risk in East Asian men.

Authors:  Christian Daniel Fankhauser; Hugh Mostafid
Journal:  Transl Androl Urol       Date:  2018-05

Review 4.  Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance.

Authors:  Bao Q Lam; Rashmi Srivastava; Jason Morvant; Sharmila Shankar; Rakesh K Srivastava
Journal:  Cells       Date:  2021-11-08       Impact factor: 6.600

5.  Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5 -/- mice, decreases plasma cholesterol and epididymal fat deposition.

Authors:  Sunil Veeravalli; Dorsa Varshavi; Flora H Scott; Dorna Varshavi; Frank S Pullen; Kirill Veselkov; Ian R Phillips; Jeremy R Everett; Elizabeth A Shephard
Journal:  Front Physiol       Date:  2022-08-08       Impact factor: 4.755
  5 in total

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