| Literature DB >> 1005920 |
C Bertazzoli, L Sala, L Ballerini, T Watanabe, K Folkers.
Abstract
Rabbits were injected with adriamycin 3 days/week/7 weeks. Heart tissues of treated rabbits showed myocardial degeneration, but the tissues of controls were normal. The deficiency in the activity of the succinate dehydrogenase-coenzyme Q10 reductase in the heart tissues of the rabbits treated with adriamycin was higher (0.001 less than P less than 0.01) than that for control tissues. These data indicate a correlation of at least a part of the cardiotoxicity of adriamycin in cancer patients to inhibition of CoQ10-enzymes, since coenzyme Q10 is indispensable to bioenergetics in the myocardium of both humans and rabbit.Entities:
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Year: 1976 PMID： 1005920
Source DB: PubMed Journal: Res Commun Chem Pathol Pharmacol ISSN： 0034-5164