Cardiovascular actions of prostaglanding F2alpha; 15-me-F2alpha; F1alpha; F2beta and F1beta in the cat.

Prostaglandin F2alpha (5mug/kg, i.v.) causes an increase in pulmonary arterial pressure, decrease in systemic arterial pressure, and reflex bradycardia in the anesthetized cat. The same dose of the 15-methyl analogue of PGF2alpha produces the same triad of effects but of greater magnitude and duration. Although prostaglandins F1alpha, F2beta and F1beta also cause the same cardiovascular effects as F2alpha, there is a decrease in potency for all parameters measured, with PGF2alpha greater than PGF1alpha greater than PGF2beta greater than PGF 1beta. When compared to the actions of PGF2alpha in producing an increase in pulmonary arterial pressure, PGs F1alpha, F2beta and F1beta were less potent by approximately 10, 100, and 1000 fold respectively.