Literature DB >> 10053200

Flurbiprofen-loaded nanospheres: analysis of the matrix structure by thermal methods.

F Gamisans1, F Lacoulonche, A Chauvet, M Espina, M L García, M A Egea.   

Abstract

We report the preparation and evaluation of flurbiprofen loaded-poly-epsilon-caprolactone nanospheres obtained by solvent displacement method. Characterization by thermal methods, infrared spectroscopy and X-ray diffraction analysis can reveal the dispersion state of the drug inside the nanospheres. Such information predicts the stability of the particles and the drug release behaviour. The study has indicated the presence of a molecular dispersed system. In addition, construction of a phase diagram has allowed us to determine the drug/polymer ratios at which flurbiprofen has the highest entrapment efficiency. Copyright.

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Year:  1999        PMID： 10053200     DOI： 10.1016/s0378-5173(98)00381-0

Source DB:  PubMed          Journal:  Int J Pharm        ISSN： 0378-5173            Impact factor:   5.875


  5 in total

1.  Poly(lactide-co-glycolide) nanocapsules containing benzocaine: influence of the composition of the oily nucleus on physico-chemical properties and anesthetic activity.

Authors:  Nathalie Ferreira Silva de Melo; Renato Grillo; Viviane Aparecida Guilherme; Daniele Ribeiro de Araujo; Eneida de Paula; André Henrique Rosa; Leonardo Fernandes Fraceto
Journal:  Pharm Res       Date:  2011-04-07       Impact factor: 4.200

2.  Encapsulation of Piper cabralanum (Piperaceae) nonpolar extract in poly(methyl methacrylate) by miniemulsion and evaluation of increase in the effectiveness of antileukemic activity in K562 cells.

Authors:  Anderson Nogueira Mendes; Lívia Alves Filgueiras; Monica Regina Pimentel Siqueira; Gleyce Moreno Barbosa; Carla Holandino; Davyson de Lima Moreira; José Carlos Pinto; Marcio Nele
Journal:  Int J Nanomedicine       Date:  2017-11-21

3.  Clarithromycin-Loaded Poly (Lactic-co-glycolic Acid) (PLGA) Nanoparticles for Oral Administration: Effect of Polymer Molecular Weight and Surface Modification with Chitosan on Formulation, Nanoparticle Characterization and Antibacterial Effects.

Authors:  A Alper Öztürk; Evrim Yenilmez; Mustafa Güçlü Özarda
Journal:  Polymers (Basel)       Date:  2019-10-09       Impact factor: 4.329

4.  Nanoparticles Based on Chitosan as Carriers for the Combined Herbicides Imazapic and Imazapyr.

Authors:  Cintia Rodrigues Maruyama; Mariana Guilger; Mônica Pascoli; Natalia Bileshy-José; P C Abhilash; Leonardo Fernandes Fraceto; Renata de Lima
Journal:  Sci Rep       Date:  2016-01-27       Impact factor: 4.379

5.  Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization.

Authors:  Elena Sánchez-López; Miren Ettcheto; Maria Antonia Egea; Marta Espina; Amanda Cano; Ana Cristina Calpena; Antoni Camins; Nuria Carmona; Amélia M Silva; Eliana B Souto; Maria Luisa García
Journal:  J Nanobiotechnology       Date:  2018-03-27       Impact factor: 10.435
  5 in total

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