BACKGROUND: Nitrogen dioxide (NO2) is a toxic by-product of inhalation therapy with nitric oxide (NO). The rate of NO2 formation during NO therapy is controversial. METHODS: The formation of NO2 was studied under dynamic flows emulating a base case NO ventilator mixture containing 80 ppm NO in a 90% oxygen matrix. The difficulty in measuring NO2 concentrations below 2 ppm accurately was overcome by the use of tunable diode laser absorption spectroscopy. RESULTS: Using a second-order model, the rate constant, k, for NO2 formation was determined to be (1.19 +/- 0.11) x 10(-11) ppm-2s-1, which is in basic agreement with evaluated data from atmospheric literature. CONCLUSIONS: Inhaled NO can be delivered safely in a well-designed, continuous flow neonatal ventilatory circuit, and NO2 formation can be calculated reliably using the rate constant and circuit dwell time.
BACKGROUND:Nitrogen dioxide (NO2) is a toxic by-product of inhalation therapy with nitric oxide (NO). The rate of NO2 formation during NO therapy is controversial. METHODS: The formation of NO2 was studied under dynamic flows emulating a base case NO ventilator mixture containing 80 ppm NO in a 90% oxygen matrix. The difficulty in measuring NO2 concentrations below 2 ppm accurately was overcome by the use of tunable diode laser absorption spectroscopy. RESULTS: Using a second-order model, the rate constant, k, for NO2 formation was determined to be (1.19 +/- 0.11) x 10(-11) ppm-2s-1, which is in basic agreement with evaluated data from atmospheric literature. CONCLUSIONS: Inhaled NO can be delivered safely in a well-designed, continuous flow neonatal ventilatory circuit, and NO2 formation can be calculated reliably using the rate constant and circuit dwell time.
Authors: Gergely Lautner; Orsolya Lautner-Csorba; Blake Stringer; Mark E Meyerhoff; Steven P Schwendeman Journal: J Control Release Date: 2019-11-25 Impact factor: 9.776
Authors: Gerald S Zavorsky; Arlin B Blood; Gordon G Power; Lawrence D Longo; Raul Artal; Emanuel J Vlastos Journal: Respir Physiol Neurobiol Date: 2010-02-10 Impact factor: 1.931
Authors: Stefan Muenster; Arkadi Beloiartsev; Binglan Yu; E Du; Sabia Abidi; Ming Dao; Gregor Fabry; Jan A Graw; Martin Wepler; Rajeev Malhotra; Bernadette O Fernandez; Martin Feelisch; Kenneth D Bloch; Donald B Bloch; Warren M Zapol Journal: Anesthesiology Date: 2016-11 Impact factor: 7.892
Authors: Yu Qin; Joanna Zajda; Elizabeth J Brisbois; Hang Ren; John M Toomasian; Terry C Major; Alvaro Rojas-Pena; Benjamin Carr; Thomas Johnson; Jonathan W Haft; Robert H Bartlett; Andrew P Hunt; Nicolai Lehnert; Mark E Meyerhoff Journal: Mol Pharm Date: 2017-10-25 Impact factor: 4.939