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Literature DB >> 10051644

Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat.

Z Qi¹, N Atsuchi, A Ooshima, A Takeshita, H Ueno.

Abstract

We eliminated type beta transforming growth factor (TGF-beta) signaling by adenovirus-mediated local expression of a dominant-negative type II TGF-beta receptor (AdCATbeta-TR) in the liver of rats treated with dimethylnitrosamine, a model of persistent liver fibrosis. In rats that received a single application of AdCATbeta-TR via the portal vein, liver fibrosis as assessed by histology and hydroxyproline content was markedly attenuated. All AdCATbeta-TR-treated rats remained alive, and their serum levels of hyaluronic acid and transaminases remained at low levels, whereas all the AdCATbeta-TR-untreated rats died of liver dysfunction. The results demonstrate that TGF-beta does play a central role in liver fibrogenesis and indicate clearly in a persistent fibrosis model that prevention of fibrosis by anti-TGF-beta intervention could be therapeutically useful.

Entities: Chemical Disease Gene Species

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Year: 1999 PMID： 10051644 PMCID： PMC26786 DOI： 10.1073/pnas.96.5.2345

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

44 in total

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