| Literature DB >> 10050667 |
K A Kaufman1, J A Bowen, A F Tsai, J A Bluestone, J S Hunt, C Ober.
Abstract
In order to elucidate the mechanisms that ensure survival of the allogeneic fetus, we are investigating the expression pattern of genes that are involved in peripheral self-tolerance in tissues at the maternal-fetal interface. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a negative regulator of T cell activation and may modulate peripheral self-tolerance. Previously, we reported the preferential transmission of maternally-inherited shorter alleles at a 3'-UTR microsatellite locus to liveborn children, but random transmission of paternally-inherited alleles, suggesting that CTLA-4 may be involved in the maintenance of tolerance at the maternal-fetal interface. In this report, we demonstrate that CTLA-4 mRNA and protein are indeed expressed in fetal tissues at the maternal-fetal interface throughout gestation.Entities:
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Year: 1999 PMID： 10050667 DOI： 10.1093/molehr/5.1.84
Source DB: PubMed Journal: Mol Hum Reprod ISSN： 1360-9947 Impact factor: 4.025