Literature DB >> 10049316

Dynamics of plaque formation in Alzheimer's disease.

B Urbanc1, L Cruz, S V Buldyrev, S Havlin, M C Irizarry, H E Stanley, B T Hyman.   

Abstract

Plaques that form in the brains of Alzheimer patients are made of deposits of the amyloid-beta peptide. We analyze the time evolution of amyloid-beta deposition in immunostained brain slices from transgenic mice. We find that amyloid-beta deposits appear in clusters whose characteristic size increases from 14 microm in 8-month-old mice to 22 microm in 12-month-old mice. We show that the clustering has implications for the biological growth of amyloid-beta by presenting a growth model that accounts for the experimentally observed structure of individual deposits and predicts the formation of clusters of deposits and their time evolution.

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Year:  1999        PMID： 10049316      PMCID： PMC1300112          DOI： 10.1016/S0006-3495(99)77295-4

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  14 in total

1.  Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

Authors:  M C Irizarry; F Soriano; M McNamara; K J Page; D Schenk; D Games; B T Hyman
Journal:  J Neurosci       Date:  1997-09-15       Impact factor: 6.167

2.  Clustering of independently diffusing individuals by birth and death processes.

Authors: 
Journal:  Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics       Date:  1996-11

3.  Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils.

Authors:  J El Khoury; S E Hickman; C A Thomas; L Cao; S C Silverstein; J D Loike
Journal:  Nature       Date:  1996-08-22       Impact factor: 49.962

Review 4.  Alzheimer's disease: a central role for amyloid.

Authors:  D J Selkoe
Journal:  J Neuropathol Exp Neurol       Date:  1994-09       Impact factor: 3.685

5.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

Authors:  A Goate; M C Chartier-Harlin; M Mullan; J Brown; F Crawford; L Fidani; L Giuffra; A Haynes; N Irving; L James
Journal:  Nature       Date:  1991-02-21       Impact factor: 49.962

6.  Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor.

Authors:  D M Paresce; R N Ghosh; F R Maxfield
Journal:  Neuron       Date:  1996-09       Impact factor: 17.173

7.  Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease.

Authors:  P V Arriagada; J H Growdon; E T Hedley-Whyte; B T Hyman
Journal:  Neurology       Date:  1992-03       Impact factor: 9.910

8.  The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution.

Authors:  B T Hyman; K Marzloff; P V Arriagada
Journal:  J Neuropathol Exp Neurol       Date:  1993-11       Impact factor: 3.685

9.  Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.

Authors:  D Games; D Adams; R Alessandrini; R Barbour; P Berthelette; C Blackwell; T Carr; J Clemens; T Donaldson; F Gillespie
Journal:  Nature       Date:  1995-02-09       Impact factor: 49.962

10.  Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

Authors:  X D Cai; T E Golde; S G Younkin
Journal:  Science       Date:  1993-01-22       Impact factor: 47.728
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  18 in total

1.  Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model.

Authors:  John F Reilly; Dora Games; Russell E Rydel; Stephen Freedman; Dale Schenk; Warren G Young; John H Morrison; Floyd E Bloom
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-15       Impact factor: 11.205

2.  Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.

Authors:  R H Christie; B J Bacskai; W R Zipfel; R M Williams; S T Kajdasz; W W Webb; B T Hyman
Journal:  J Neurosci       Date:  2001-02-01       Impact factor: 6.167

3.  Stable size distribution of amyloid plaques over the course of Alzheimer disease.

Authors:  Alberto Serrano-Pozo; Matthew L Mielke; Alona Muzitansky; Teresa Gómez-Isla; John H Growdon; Brian J Bacskai; Rebecca A Betensky; Matthew P Frosch; Bradley T Hyman
Journal:  J Neuropathol Exp Neurol       Date:  2012-08       Impact factor: 3.685

4.  Stability analysis of a steady state of a model describing Alzheimer's disease and interactions with prion proteins.

Authors:  Mohammed Helal; Angélique Igel-Egalon; Abdelkader Lakmeche; Pauline Mazzocco; Angélique Perrillat-Mercerot; Laurent Pujo-Menjouet; Human Rezaei; Léon M Tine
Journal:  J Math Biol       Date:  2018-08-11       Impact factor: 2.259

5.  Size frequency distribution of prion protein (PrP) aggregates in variant Creutzfeldt-Jakob disease (vCJD).

Authors:  R A Armstrong; N J Cairns; J W Ironside; P L Lantos
Journal:  J Neural Transm (Vienna)       Date:  2005-03-23       Impact factor: 3.575

6.  A qualitative model for aggregation and diffusion of β-amyloid in Alzheimer's disease.

Authors:  Yves Achdou; Bruno Franchi; Norina Marcello; Maria Carla Tesi
Journal:  J Math Biol       Date:  2012-09-27       Impact factor: 2.259

7.  Computational modeling of the relationship between amyloid and disease.

Authors:  Damien Hall; Herman Edskes
Journal:  Biophys Rev       Date:  2012-09

8.  Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers.

Authors:  Lina Adwan; Gehad M Subaiea; Nasser H Zawia
Journal:  Neuropharmacology       Date:  2014-01-21       Impact factor: 5.250

9.  Size frequency distribution of the beta-amyloid (abeta) deposits in dementia with Lewy bodies with associated Alzheimer's disease pathology.

Authors:  Richard A Armstrong; Nigel J Cairns
Journal:  Neurol Sci       Date:  2009-09-19       Impact factor: 3.307

10.  Exploring a mathematical model for the kinetics of beta-amyloid molecular imaging probes through a critical analysis of plaque pathology.

Authors:  Kooresh Shoghi-Jadid; Jorge R Barrio; Vladimir Kepe; Sung-Cheng Huang
Journal:  Mol Imaging Biol       Date:  2006 May-Jun       Impact factor: 3.488
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