Literature DB >> 10049299

Lactic acid polymers as biodegradable carriers of fluoroquinolones: an in vitro study.

K Kanellakopoulou1, M Kolia, A Anastassiadis, T Korakis, E J Giamarellos-Bourboulis, A Andreopoulos, E Dounis, H Giamarellou.   

Abstract

A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described. Duration and peak of release were found to depend on the molecular weight of the polymer. Its characteristics make it promising for treating chronic bone infections.

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Year:  1999        PMID： 10049299      PMCID： PMC89192     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Controlled release of antibiotics from coated orthopedic implants.

Authors:  J S Price; A F Tencer; D M Arm; G A Bohach
Journal:  J Biomed Mater Res       Date:  1996-03

2.  In vitro release of new quinolones from biodegradable systems: a comparative study.

Authors:  A G Andreopoulos; T Korakis; E Dounis; A Anastasiadis; P Tzivelekis; K Kanellakopoulou
Journal:  J Biomater Appl       Date:  1996-04       Impact factor: 2.646

3.  Chronic osteomyelitis caused by multi-resistant Gram-negative bacteria: evaluation of treatment with newer quinolones after prolonged follow-up.

Authors:  N Galanakis; H Giamarellou; T Moussas; E Dounis
Journal:  J Antimicrob Chemother       Date:  1997-02       Impact factor: 5.790

4.  A bioabsorbable delivery system for antibiotic treatment of osteomyelitis. The use of lactic acid oligomer as a carrier.

Authors:  G Wei; Y Kotoura; M Oka; T Yamamuro; R Wada; S H Hyon; Y Ikada
Journal:  J Bone Joint Surg Br       Date:  1991-03

5.  Penetration of ciprofloxacin into bone: a new bioabsorbable implant.

Authors:  J P Overbeck; S T Winckler; R Meffert; P Törmälä; H U Spiegel; E Brug
Journal:  J Invest Surg       Date:  1995 May-Jun       Impact factor: 2.533

6.  Polylactide/polyglycolide antibiotic implants in the treatment of osteomyelitis. A canine model.

Authors:  K L Garvin; J A Miyano; D Robinson; D Giger; J Novak; S Radio
Journal:  J Bone Joint Surg Am       Date:  1994-10       Impact factor: 5.284

7.  Pharmacokinetic study of fibrin clot-ciprofloxacin complex: an in vitro and in vivo experimental investigation.

Authors:  S Tsourvakas; P Hatzigrigoris; A Tsibinos; K Kanellakopoulou; H Giamarellou; E Dounis
Journal:  Arch Orthop Trauma Surg       Date:  1995       Impact factor: 3.067

Review 8.  Activity of quinolones against gram-positive cocci: clinical features.

Authors:  H Giamarellou
Journal:  Drugs       Date:  1995       Impact factor: 9.546

Review 9.  Quinolones and osteomyelitis: state-of-the-art.

Authors:  D P Lew; F A Waldvogel
Journal:  Drugs       Date:  1995       Impact factor: 9.546

10.  In vitro elution of ciprofloxacin from polymethylmethacrylate cement beads.

Authors:  F R DiMaio; J J O'Halloran; J M Quale
Journal:  J Orthop Res       Date:  1994-01       Impact factor: 3.494
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  5 in total

1.  Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus.

Authors:  Jyri K Koort; Tatu J Mäkinen; Esa Suokas; Minna Veiranto; Jari Jalava; Juhani Knuuti; Pertti Törmälä; Hannu T Aro
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

Review 2.  Carrier systems for the local delivery of antibiotics in bone infections.

Authors:  K Kanellakopoulou; E J Giamarellos-Bourboulis
Journal:  Drugs       Date:  2000-06       Impact factor: 9.546

3.  Carboxymethyl cellulose (CMC) based semi-IPNs as carriers for controlled release of ciprofloxacine: an in-vitro dynamic study.

Authors:  A K Bajpai; Abhilasha Mishra
Journal:  J Mater Sci Mater Med       Date:  2007-11-08       Impact factor: 3.896

4.  Local treatment of experimental Pseudomonas aeruginosa osteomyelitis with a biodegradable dilactide polymer releasing ciprofloxacin.

Authors:  Kyriaki Kanellakopoulou; George C Thivaios; Maria Kolia; Ismini Dontas; Lydia Nakopoulou; Eleftherios Dounis; Evangelos J Giamarellos-Bourboulis; Andreas Andreopoulos; Panayotis Karagiannakos; Helen Giamarellou
Journal:  Antimicrob Agents Chemother       Date:  2008-04-14       Impact factor: 5.191

5.  In vitro elution characteristics of gentamicin and vancomycin from synthetic bone graft substitutes.

Authors:  Gerrit Steffen Maier; Klaus Edgar Roth; Stefan Andereya; Klaus Birnbaum; Christopher Niedhart; Markus Lühmann; Jörg Ohnsorge; Uwe Maus
Journal:  Open Orthop J       Date:  2013-11-03
  5 in total

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