Literature DB >> 10049289

Multiplex sequence analysis demonstrates the competitive growth advantage of the A-to-G mutants of clarithromycin-resistant Helicobacter pylori.

G Wang1, M S Rahman, M Z Humayun, D E Taylor.   

Abstract

Clarithromycin resistance in Helicobacter pylori is due to point mutation within the 23S rRNA. We examined the growth rates of different types of site-directed mutants and demonstrated quantitatively the competitive growth advantage of A-to-G mutants over other types of mutants by a multiplex sequencing assay. The results provide a rational explanation of why A-to-G mutants are predominantly observed among clarithromycin-resistant clinical isolates.

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Year:  1999        PMID： 10049289      PMCID： PMC89182     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Antimicrobial resistance and Helicobacter pylori.

Authors:  A F Goddard; R P Logan
Journal:  J Antimicrob Chemother       Date:  1996-04       Impact factor: 5.790

2.  A PCR-oligonucleotide ligation assay to determine the prevalence of 23S rRNA gene mutations in clarithromycin-resistant Helicobacter pylori.

Authors:  G G Stone; D Shortridge; J Versalovic; J Beyer; R K Flamm; D Y Graham; A T Ghoneim; S K Tanaka
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

3.  Macrolide resistance in Helicobacter pylori: rapid detection of point mutations and assays of macrolide binding to ribosomes.

Authors:  A Occhialini; M Urdaci; F Doucet-Populaire; C M Bébéar; H Lamouliatte; F Mégraud
Journal:  Antimicrob Agents Chemother       Date:  1997-12       Impact factor: 5.191

4.  Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations.

Authors:  D E Taylor; Z Ge; D Purych; T Lo; K Hiratsuka
Journal:  Antimicrob Agents Chemother       Date:  1997-12       Impact factor: 5.191

5.  Effect of UVM induction on mutation fixation at non-pairing and mispairing DNA lesions.

Authors:  M S Rahman; P M Dunman; G Wang; H S Murphy; M Z Humayun
Journal:  Mol Microbiol       Date:  1996-11       Impact factor: 3.501

6.  Site-specific mutations in the 23S rRNA gene of Helicobacter pylori confer two types of resistance to macrolide-lincosamide-streptogramin B antibiotics.

Authors:  G Wang; D E Taylor
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191

7.  Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori.

Authors:  J Versalovic; D Shortridge; K Kibler; M V Griffy; J Beyer; R K Flamm; S K Tanaka; D Y Graham; M F Go
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

8.  Alkylating agents induce UVM, a recA-independent inducible mutagenic phenomenon in Escherichia coli.

Authors:  G Wang; V A Palejwala; P M Dunman; D H Aviv; H S Murphy; M S Rahman; M Z Humayun
Journal:  Genetics       Date:  1995-11       Impact factor: 4.562

9.  Quantitative multiplex sequence analysis of mutational hot spots. Frequency and specificity of mutations induced by a site-specific ethenocytosine in M13 viral DNA.

Authors:  V A Palejwala; R W Rzepka; D Simha; M Z Humayun
Journal:  Biochemistry       Date:  1993-04-20       Impact factor: 3.162

10.  Explaining the bias in the 23S rRNA gene mutations associated with clarithromycin resistance in clinical isolates of Helicobacter pylori.

Authors:  Y J Debets-Ossenkopp; A B Brinkman; E J Kuipers; C M Vandenbroucke-Grauls; J G Kusters
Journal:  Antimicrob Agents Chemother       Date:  1998-10       Impact factor: 5.191
View more
  10 in total

1.  Rapid detection of mutations in the 23S rRNA gene of Helicobacter pylori that confers resistance to clarithromycin treatment to the bacterium.

Authors:  M Matsumura; Y Hikiba; K Ogura; G Togo; I Tsukuda; K Ushikawa; Y Shiratori; M Omata
Journal:  J Clin Microbiol       Date:  2001-02       Impact factor: 5.948

Review 2.  Macrolide resistance conferred by base substitutions in 23S rRNA.

Authors:  B Vester; S Douthwaite
Journal:  Antimicrob Agents Chemother       Date:  2001-01       Impact factor: 5.191

3.  Effect of drug concentration on emergence of macrolide resistance in Mycobacterium avium.

Authors:  K A Nash
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

4.  Nucleotide sequence-based multitarget identification.

Authors:  T Vinayagamoorthy; Kirk Mulatz; Roger Hodkinson
Journal:  J Clin Microbiol       Date:  2003-07       Impact factor: 5.948

5.  Biological cost of rifampin resistance from the perspective of Staphylococcus aureus.

Authors:  Thomas A Wichelhaus; Boris Böddinghaus; Silke Besier; Volker Schäfer; Volker Brade; Albrecht Ludwig
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

6.  Clarithromycin-susceptible and -resistant Helicobacter pylori isolates with identical randomly amplified polymorphic DNA-PCR genotypes cultured from single gastric biopsy specimens prior to antibiotic therapy.

Authors:  A van der Ende; L J van Doorn; S Rooijakkers; M Feller; G N Tytgat; J Dankert
Journal:  J Clin Microbiol       Date:  2001-07       Impact factor: 5.948

7.  Spontaneous mutations that confer antibiotic resistance in Helicobacter pylori.

Authors:  G Wang; T J Wilson; Q Jiang; D E Taylor
Journal:  Antimicrob Agents Chemother       Date:  2001-03       Impact factor: 5.191

8.  Helicobacter pylori primary resistance to metronidazole and clarithromycin in Brazil.

Authors:  Paula Prazeres Magalhães; Dulciene Maria De Magalhães Queiroz; Daniela Vale Campos Barbosa; Gifone Aguiar Rocha; Edilberto Nogueira Mendes; Adriana Santos; Paulo Renato Valle Corrêa; Andreia Maria Camargos Rocha; Lúcia Martins Teixeira; Celso Affonso de Oliveira
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

Review 9.  Mechanisms of Helicobacter pylori antibiotic resistance and molecular testing.

Authors:  Toshihiro Nishizawa; Hidekazu Suzuki
Journal:  Front Mol Biosci       Date:  2014-10-24

10.  Development of a high throughput human stool specimen processing method for a molecular Helicobacter pylori clarithromycin resistance assay.

Authors:  Natalie Clines; Erin Beckman
Journal:  PLoS One       Date:  2019-12-16       Impact factor: 3.240
  10 in total

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