Literature DB >> 10049287

Influence of renal failure on intestinal clearance of ciprofloxacin in rats.

S Dautrey1, L Rabbaa, D Laouari, B Lacour, C Carbon, R Farinotti.   

Abstract

Following intravenous doses, ciprofloxacin pharmacokinetics in control and nephrectomized rats were studied. There were no differences between control and nephrectomized rats for area under the concentration-time curve in plasma or biliary clearance. The intestinal clearance of ciprofloxacin was increased in nephrectomized rats. Intestinal elimination seems to compensate partially for the decrease in urinary excretion of ciprofloxacin in nephrectomized rats.

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Year:  1999        PMID： 10049287      PMCID： PMC89180     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Absorption of drugs from the rat small intestine.

Authors:  L S SCHANKER; D J TOCCO; B B BRODIE; C A HOGBEN
Journal:  J Pharmacol Exp Ther       Date:  1958-05       Impact factor: 4.030

2.  Transintestinal elimination of ciprofloxacin.

Authors:  R Rohwedder; T Bergan; S B Thorsteinsson; H Scholl
Journal:  Chemotherapy       Date:  1990       Impact factor: 2.544

3.  Comparison of models for studying the intestinal elimination of ciprofloxacin in the rat.

Authors:  S Dautrey; L Rabbaa; A Petiet; C Carbon; R Farinotti
Journal:  Drugs       Date:  1995       Impact factor: 9.546

4.  The intestinal elimination of ciprofloxacin in the rat.

Authors:  E Rubinstein; L St Julien; J Ramon; S Dautrey; R Farinotti; J F Huneau; C Carbon
Journal:  J Infect Dis       Date:  1994-01       Impact factor: 5.226

5.  Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells.

Authors:  M E Cavet; M West; N L Simmons
Journal:  Br J Pharmacol       Date:  1997-08       Impact factor: 8.739

6.  Dose-ranging pharmacokinetic study of ciprofloxacin after 200-, 300-, and 400-mg intravenous doses.

Authors:  D E Nix; J M Spivey; A Norman; J J Schentag
Journal:  Ann Pharmacother       Date:  1992-01       Impact factor: 3.154

7.  Influence of renal failure on ciprofloxacin pharmacokinetics in rats.

Authors:  B Nouaille-Degorce; C Veau; S Dautrey; M Tod; D Laouari; C Carbon; R Farinotti
Journal:  Antimicrob Agents Chemother       Date:  1998-02       Impact factor: 5.191

8.  Glomerular response to acute protein load is not blunted by high-protein diet or nephron reduction.

Authors:  M Burtin; D Laouari; C Kindermans; C Kleinknecht
Journal:  Am J Physiol       Date:  1994-05

9.  Active secretion of the fluoroquinolone ciprofloxacin by human intestinal epithelial Caco-2 cell layers.

Authors:  N M Griffiths; B H Hirst; N L Simmons
Journal:  Br J Pharmacol       Date:  1993-03       Impact factor: 8.739

10.  Pharmacokinetics of ciprofloxacin. 1st communication: absorption, concentrations in plasma, metabolism and excretion after a single administration of [14C]ciprofloxacin in albino rats and rhesus monkeys.

Authors:  H M Siefert; D Maruhn; W Maul; D Förster; W Ritter
Journal:  Arzneimittelforschung       Date:  1986-10
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  3 in total

1.  Active intestinal elimination of ciprofloxacin in rats: modulation by different substrates.

Authors:  S Dautrey; K Felice; A Petiet; B Lacour; C Carbon; R Farinotti
Journal:  Br J Pharmacol       Date:  1999-08       Impact factor: 8.739

2.  Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats.

Authors:  Hiroaki Yamaguchi; Ikuko Yano; Hideyuki Saito; Ken-ichi Inui
Journal:  Pharm Res       Date:  2004-02       Impact factor: 4.200

3.  Population pharmacokinetics and target attainment of ciprofloxacin in critically ill patients.

Authors:  Alan Abdulla; Omar Rogouti; Nicole G M Hunfeld; Henrik Endeman; Annemieke Dijkstra; Teun van Gelder; Anouk E Muller; Brenda C M de Winter; Birgit C P Koch
Journal:  Eur J Clin Pharmacol       Date:  2020-04-19       Impact factor: 2.953
  3 in total

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