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Literature DB >> 10048487

Characterization of a Caenorhabditis elegans recA-like gene Ce-rdh-1 involved in meiotic recombination.

T Takanami¹, S Sato, T Ishihara, I Katsura, H Takahashi, A Higashitani.

Abstract

A recA-like gene was identified in the Caenorhabditis elegans genome project database. The putative product of the gene, termed Ce-rdh-1 (C. elegans RAD51 and DMC1/LIM15 homolog 1), consists of 357 amino acid residues. The predicted amino acid sequence of Ce-rdh-1 showed 46-60% identity to both RAD51 type and DMC1/LIM15 type genes in several eukaryote species. The results of RNAi (RNA-mediated interference) indicated that repression of Ce-rdh-1 blocked chromosome condensation of six bivalents and dissociation of chiasmata in oocytes of F1 progeny. Oogenesis did not proceed to the diakinesis stage. Accordingly, all the eggs produced (F2) died in early stages. These results suggest that Ce-rdh-1 participates in meiotic recombination.

Entities: Gene Species

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Year: 1998 PMID： 10048487 DOI： 10.1093/dnares/5.6.373

Source DB: PubMed Journal: DNA Res ISSN： 1340-2838 Impact factor: 4.458

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Cited

17 in total

1. Hyper-resistance of meiotic cells to radiation due to a strong expression of a single recA-like gene in Caenorhabditis elegans.

Authors: T Takanami; A Mori; H Takahashi; A Higashitani
Journal: Nucleic Acids Res Date: 2000-11-01 Impact factor: 16.971

10. Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line.

Authors: Chantal Wicky; Arno Alpi; Myriam Passannante; Ann Rose; Anton Gartner; Fritz Müller
Journal: Mol Cell Biol Date: 2004-06 Impact factor: 4.272

Characterization of a Caenorhabditis elegans recA-like gene Ce-rdh-1 involved in meiotic recombination.

1. Hyper-resistance of meiotic cells to radiation due to a strong expression of a single recA-like gene in Caenorhabditis elegans.

2. SERK and APOSTART. Candidate genes for apomixis in Poa pratensis.

3. A Role in Apoptosis Regulation for the rad-51 Gene of Caenorhabditis elegans.

4. Genome-wide analysis of mRNA targets for Caenorhabditis elegans FBF, a conserved stem cell regulator.

5. Meiotic Double-Strand Break Proteins Influence Repair Pathway Utilization.

6. Genetic and cytological characterization of the recombination protein RAD-51 in Caenorhabditis elegans.

7. Roles for Caenorhabditis elegans rad-51 in meiosis and in resistance to ionizing radiation during development.

8. Transcriptional silencing of a transgene by RNAi in the soma of C. elegans.

9. Caenorhabditis elegans Ce-rdh-1/rad-51 functions after double-strand break formation of meiotic recombination.

10. Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line.